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• W2340632910 abstract "Objetivo: Avaliar a relacao entre o padrao de uso da cocaina e a perfusao cerebral de dependentes da substância. Metodos: Estudou-se uma amostra de 30 dependentes de cocaina por meio de tomografia computadorizada por emissao de foton unico (single photon emission computed tomography – SPECT) com hexametil-propilenoamina-oxima, marcada com tecnecio 99 m (99 m-Tc-HMPAO), e comparou-se o padrao de perfusao cerebral com o padrao de consumo da droga. Resultados: Dos dependentes, 80% apresentaram alteracoes de perfusao cerebral, focais ou difusas, com grau de intensidade variavel. Nao foram observadas diferencas de perfusao cerebral entre usuarios de crack e usuarios de cloridrato de cocaina. As alteracoes tomograficas tampouco permitiram distinguir os dependentes em abstinencia dos dependentes na vigencia do uso. Nao foi possivel evidenciar associacao entre o relato da quantidade diaria de droga utilizada e a perfusao cerebral dos pacientes. Entretanto, foi observada correlacao entre o numero de meses durante os quais os pacientes consumiram droga e o grau de comprometimento da perfusao cerebral (coeficiente de correlacao de Spearman: r=0,45, p<0,05). Conclusao: Este estudo documenta a frequencia elevada de alteracoes funcionais cerebrais em dependentes de cocaina, estabelecendo a influencia do tempo de consumo da droga no grau de comprometimento do fluxo cerebral dos pacientes. Cocaina. Cocaina Crack. Drogas ilicitas. Circulacao cerebrovascular. SPECT. Objective: To evaluate the relationship between the pattern of cocaine use and cerebral perfusion among cocaine addicts. Method: A sample of 30 cocaine addicts was studied using 99 m-Tc-HMPAO SPECT (single photon emission computed tomography with injection of 99 m-Tc-hexametilpropilenoamina-oxime). Their cerebral perfusion pattern was then compared with their pattern of cocaine use. Results: Eighty percent of the sample presented some degree of impairment in brain perfusion, either focal or diffuse. There was no difference between sniffers and crack smokers regarding their perfusion patterns. No relationship could be established between the severity of SPECT abnormalities and the amount of drug consumption or period of abstinence. However, length of cocaine use did correlate with the severity of cerebral perfusion (Spearman correlation coefficient: r=0.45, p<0.05). Conclusion: This study documents the high frequency of cerebral functional impairment in cocaine addicts and establishes the relationship between length of cocaine exposure and severity of perfusion abnormalities. Cocaine. Crack cocaine. Street drugs. Cerebrovascular circulation. SPECT." @default.
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• W2340632910 date "2001-01-01" @default.
• W2340632910 modified "2023-09-27" @default.
• W2340632910 title "Fatores associados a perfusão cerebral anormal em dependentes de cocaína Factors related to abnormal brain perfusion in cocaine addicts" @default.
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