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- W2340694209 abstract "The effect of the peptide substance on the induced production of histamine by culture of basophile, interaction of the preparation with the H1-histamine receptors and possible sedative effect on animal models were studied. The introduction of the peptide substance in cell culture of basophile didn’t have a significant effect on the histamine release. Study of the interaction of the polypeptide substance with H1-histamine receptors of guinea pig ileum showed that the preparation inhibits the response of unstriated muscles to histamine. The effect was similar to antihistamine drug - ketotifen. In the models of “open field” and “elevated criss-cross labyrinth” it was found that the peptide preparation hasn’t a sedative effect." @default.
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- W2340694209 date "2012-12-15" @default.
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- W2340694209 title "Antihistamine activity of the new peptidepreparation from the cod liver" @default.
- W2340694209 doi "https://doi.org/10.17816/rcf10449-53" @default.
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