Matches in SemOpenAlex for { <https://semopenalex.org/work/W2340733747> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2340733747 abstract "Isolated platelets are strongly sensitized by the presence of low-density lipoproteins (LDL) so that they aggregate with very low concentrations of other agonists or exhibit spontaneous aggregation. Prostacyclin (PGI2) is a potent inhibitor of aggregation, but its action was reversed by LDL. This effect of LDL was accompanied by a decrease in the synthesis of cyclic AMP induced by PGI2, but its efficacy depended on the relative concentrations of LDL and PGI2. PGI2 also enhanced the synthesis of cyclic GMP, but this was completely reversed by the presence of LDL. LDL did not remove inhibitory prostaglandins, e.g. E1, from their receptor sites. The lipoproteins also decreased cyclic AMP synthesis induced by forskolin, which has its effect on the GTP-sensitive protein or the catalytic unit of the adenylate cyclase enzyme complex. It is proposed that LDL may act on the enzyme catalytic unit via an inhibitory GTP-sensitive protein or by a separate mechanism which indirectly impedes the production of cyclic AMP." @default.
- W2340733747 created "2016-06-24" @default.
- W2340733747 creator A5019414568 @default.
- W2340733747 creator A5071186989 @default.
- W2340733747 creator A5085185873 @default.
- W2340733747 date "1984-10-01" @default.
- W2340733747 modified "2023-10-16" @default.
- W2340733747 title "The effect of low-density lipoproteins on the synthesis of cyclic nucleotides induced by prostacyclin in isolated platelets" @default.
- W2340733747 cites W1518913349 @default.
- W2340733747 cites W1529369520 @default.
- W2340733747 cites W1535668052 @default.
- W2340733747 cites W1560558171 @default.
- W2340733747 cites W1592645167 @default.
- W2340733747 cites W1811100095 @default.
- W2340733747 cites W191820774 @default.
- W2340733747 cites W1965587893 @default.
- W2340733747 cites W2010291027 @default.
- W2340733747 cites W2026079918 @default.
- W2340733747 cites W2029058981 @default.
- W2340733747 cites W2029134608 @default.
- W2340733747 cites W2029466610 @default.
- W2340733747 cites W2044723736 @default.
- W2340733747 cites W2062185761 @default.
- W2340733747 cites W2075676530 @default.
- W2340733747 cites W2078593416 @default.
- W2340733747 cites W2103200056 @default.
- W2340733747 cites W2319269635 @default.
- W2340733747 cites W2413893349 @default.
- W2340733747 cites W2417379444 @default.
- W2340733747 cites W2462361441 @default.
- W2340733747 cites W2472533830 @default.
- W2340733747 cites W83534692 @default.
- W2340733747 doi "https://doi.org/10.1042/bj2230189" @default.
- W2340733747 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1144279" @default.
- W2340733747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6093767" @default.
- W2340733747 hasPublicationYear "1984" @default.
- W2340733747 type Work @default.
- W2340733747 sameAs 2340733747 @default.
- W2340733747 citedByCount "27" @default.
- W2340733747 crossrefType "journal-article" @default.
- W2340733747 hasAuthorship W2340733747A5019414568 @default.
- W2340733747 hasAuthorship W2340733747A5071186989 @default.
- W2340733747 hasAuthorship W2340733747A5085185873 @default.
- W2340733747 hasBestOaLocation W23407337472 @default.
- W2340733747 hasConcept C104317684 @default.
- W2340733747 hasConcept C118716 @default.
- W2340733747 hasConcept C126322002 @default.
- W2340733747 hasConcept C134018914 @default.
- W2340733747 hasConcept C170493617 @default.
- W2340733747 hasConcept C17077164 @default.
- W2340733747 hasConcept C180526460 @default.
- W2340733747 hasConcept C181199279 @default.
- W2340733747 hasConcept C185592680 @default.
- W2340733747 hasConcept C2778524494 @default.
- W2340733747 hasConcept C2779276759 @default.
- W2340733747 hasConcept C2780069284 @default.
- W2340733747 hasConcept C2781128415 @default.
- W2340733747 hasConcept C512185932 @default.
- W2340733747 hasConcept C55493867 @default.
- W2340733747 hasConcept C71924100 @default.
- W2340733747 hasConcept C86803240 @default.
- W2340733747 hasConcept C89560881 @default.
- W2340733747 hasConceptScore W2340733747C104317684 @default.
- W2340733747 hasConceptScore W2340733747C118716 @default.
- W2340733747 hasConceptScore W2340733747C126322002 @default.
- W2340733747 hasConceptScore W2340733747C134018914 @default.
- W2340733747 hasConceptScore W2340733747C170493617 @default.
- W2340733747 hasConceptScore W2340733747C17077164 @default.
- W2340733747 hasConceptScore W2340733747C180526460 @default.
- W2340733747 hasConceptScore W2340733747C181199279 @default.
- W2340733747 hasConceptScore W2340733747C185592680 @default.
- W2340733747 hasConceptScore W2340733747C2778524494 @default.
- W2340733747 hasConceptScore W2340733747C2779276759 @default.
- W2340733747 hasConceptScore W2340733747C2780069284 @default.
- W2340733747 hasConceptScore W2340733747C2781128415 @default.
- W2340733747 hasConceptScore W2340733747C512185932 @default.
- W2340733747 hasConceptScore W2340733747C55493867 @default.
- W2340733747 hasConceptScore W2340733747C71924100 @default.
- W2340733747 hasConceptScore W2340733747C86803240 @default.
- W2340733747 hasConceptScore W2340733747C89560881 @default.
- W2340733747 hasLocation W23407337471 @default.
- W2340733747 hasLocation W23407337472 @default.
- W2340733747 hasLocation W23407337473 @default.
- W2340733747 hasLocation W23407337474 @default.
- W2340733747 hasOpenAccess W2340733747 @default.
- W2340733747 hasPrimaryLocation W23407337471 @default.
- W2340733747 hasRelatedWork W1997914486 @default.
- W2340733747 hasRelatedWork W2002661707 @default.
- W2340733747 hasRelatedWork W2040741921 @default.
- W2340733747 hasRelatedWork W2045308975 @default.
- W2340733747 hasRelatedWork W2046164801 @default.
- W2340733747 hasRelatedWork W2048154889 @default.
- W2340733747 hasRelatedWork W2056306087 @default.
- W2340733747 hasRelatedWork W2169909436 @default.
- W2340733747 hasRelatedWork W2340733747 @default.
- W2340733747 hasRelatedWork W2398181117 @default.
- W2340733747 isParatext "false" @default.
- W2340733747 isRetracted "false" @default.
- W2340733747 magId "2340733747" @default.
- W2340733747 workType "article" @default.