Matches in SemOpenAlex for { <https://semopenalex.org/work/W2340739907> ?p ?o ?g. }
- W2340739907 endingPage "261" @default.
- W2340739907 startingPage "237" @default.
- W2340739907 abstract "Calcific aortic valve disease (CAVD) is a significant cause of mortality among the aging population. Because disease mechanisms are still unclear, the only current treatment option for this disease is aortic valve replacement. In order to understand the disease and develop treatment targets, we must explore the hemodynamic and mechanical forces affecting the valve, as well as the biological pathways altered by those mechanics ultimately leading to tissue calcification. The unique structure of the valve allows it to adapt to the constantly changing mechanical environment and the wide array of forces exerted upon the tissue during the cardiac cycle. CAVD results in an impairment in the structure and function of the aortic valve, resulting in pathological systemic changes. A variety of mechanosensors at the valvular endothelial cell surface are responsible for transmission of mechanical signals to alter cell phenotype and ultimate tissue function. Recently, valvular microRNAs have been discovered to be mechanosensitive, possibly regulating key signaling in the pathology of CAVD. Our understanding of the aortic valve and CAVD is evolving rapidly, and future therapies rely on further exploration of this complex disease." @default.
- W2340739907 created "2016-06-24" @default.
- W2340739907 creator A5031475167 @default.
- W2340739907 creator A5035028784 @default.
- W2340739907 creator A5060948677 @default.
- W2340739907 creator A5061670171 @default.
- W2340739907 date "2015-07-24" @default.
- W2340739907 modified "2023-10-16" @default.
- W2340739907 title "Hemodynamics and Mechanobiology of Aortic Valve Calcification" @default.
- W2340739907 cites W1501656475 @default.
- W2340739907 cites W1507413178 @default.
- W2340739907 cites W1551940170 @default.
- W2340739907 cites W1560998933 @default.
- W2340739907 cites W1599429544 @default.
- W2340739907 cites W1771887010 @default.
- W2340739907 cites W1967296654 @default.
- W2340739907 cites W1968200344 @default.
- W2340739907 cites W1969929083 @default.
- W2340739907 cites W1973506204 @default.
- W2340739907 cites W1981305352 @default.
- W2340739907 cites W1982361573 @default.
- W2340739907 cites W1984363220 @default.
- W2340739907 cites W1984956485 @default.
- W2340739907 cites W1988420157 @default.
- W2340739907 cites W1989656972 @default.
- W2340739907 cites W1990343804 @default.
- W2340739907 cites W1990932442 @default.
- W2340739907 cites W1991327393 @default.
- W2340739907 cites W1994687125 @default.
- W2340739907 cites W1995286805 @default.
- W2340739907 cites W1998826234 @default.
- W2340739907 cites W2002045481 @default.
- W2340739907 cites W2002771508 @default.
- W2340739907 cites W2004249100 @default.
- W2340739907 cites W2006497959 @default.
- W2340739907 cites W2007748353 @default.
- W2340739907 cites W2008255590 @default.
- W2340739907 cites W2008447781 @default.
- W2340739907 cites W2011126362 @default.
- W2340739907 cites W2015918571 @default.
- W2340739907 cites W2016481705 @default.
- W2340739907 cites W2016644911 @default.
- W2340739907 cites W2019415509 @default.
- W2340739907 cites W2021683914 @default.
- W2340739907 cites W2025838993 @default.
- W2340739907 cites W2030105817 @default.
- W2340739907 cites W203611039 @default.
- W2340739907 cites W2039066199 @default.
- W2340739907 cites W2039182800 @default.
- W2340739907 cites W2041065162 @default.
- W2340739907 cites W2042798441 @default.
- W2340739907 cites W2043128020 @default.
- W2340739907 cites W2044258769 @default.
- W2340739907 cites W2047567287 @default.
- W2340739907 cites W2047585541 @default.
- W2340739907 cites W2050650917 @default.
- W2340739907 cites W2054651797 @default.
- W2340739907 cites W2054844811 @default.
- W2340739907 cites W2055375869 @default.
- W2340739907 cites W2057724008 @default.
- W2340739907 cites W2058258523 @default.
- W2340739907 cites W2059122391 @default.
- W2340739907 cites W2060581558 @default.
- W2340739907 cites W2060965660 @default.
- W2340739907 cites W2062329090 @default.
- W2340739907 cites W2064119580 @default.
- W2340739907 cites W2065591461 @default.
- W2340739907 cites W2066503776 @default.
- W2340739907 cites W2069443069 @default.
- W2340739907 cites W2069674130 @default.
- W2340739907 cites W2070244277 @default.
- W2340739907 cites W2071009265 @default.
- W2340739907 cites W2071145526 @default.
- W2340739907 cites W2071831995 @default.
- W2340739907 cites W2072463503 @default.
- W2340739907 cites W2073266383 @default.
- W2340739907 cites W2074617005 @default.
- W2340739907 cites W2075923148 @default.
- W2340739907 cites W2078635122 @default.
- W2340739907 cites W2081604319 @default.
- W2340739907 cites W2081741743 @default.
- W2340739907 cites W2085051200 @default.
- W2340739907 cites W2085786505 @default.
- W2340739907 cites W2087835576 @default.
- W2340739907 cites W2090106721 @default.
- W2340739907 cites W2090250999 @default.
- W2340739907 cites W2091399349 @default.
- W2340739907 cites W2093452583 @default.
- W2340739907 cites W2093476993 @default.
- W2340739907 cites W2096523367 @default.
- W2340739907 cites W2099656010 @default.
- W2340739907 cites W2101264497 @default.
- W2340739907 cites W2103135224 @default.
- W2340739907 cites W2105624703 @default.
- W2340739907 cites W2107758711 @default.
- W2340739907 cites W2108007523 @default.
- W2340739907 cites W2109718292 @default.
- W2340739907 cites W2111396173 @default.