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• W2340757448 abstract "The autonomic nervous system (ANS) controls most involuntary functions of the body. Dysfunctions of the ANS can be life-threatening. However, several critical questions related to cardiovascular and breathing regulations remain unclear. One of the open questions is how the system lose control of the vascular tones under certain circumstances. Using the septic shock model induced by lipopolysaccharide (LPS) in isolated and perfused mesenteric arterial rings, we found the vascular hyporeactivity is attributed to the decreased vasoconstriction to α-adrenoceptor agonists. The endotoxin-induced vasodilation can be intervened with endothelin-1 (ET-1), serotonin (5-HT) or vasopressin, which have never been used in clinical treatment. It is unclear how the excitability of endothelium affects vascular tones. Using optogenetics and transgenic mice with channelrhodopsin expression in endothelial cells (ECs), we found selective activation of the ECs induces a fast, robust, reproducible and long-lasting vasoconstriction in isolated and perfused hearts and kidneys. Breathing control by the ANS within the brain becomes abnormal in certain genetic diseases, such as Rett syndrome with defected norepinephrine (NE) system in locus coeruleus (LC). The LC neurons are hyperexcitable while NE release is deficient. Using optogenetics and double transgenic mice with Mecp2 null and channelrhodopsin expression in LC neurons, we found the NE-ergic modulation of hypoglossal neurons was impaired in transgenic mice, which cannot be improved with optostimulation, suggesting that LC neuronal hyperexcitability may not benefit the NE modulation in Rett syndrome. Collectively, our results provide insight into the autonomic dysfunctions using experimental interventions that have barely been used before. INDEX WORDS: Autonomic nervous system, Dysfunction, Vascular tones, Breathing, Septic shock, Lipopolysaccharide, Endothelium, Optogenetics, Transgenic mice, Rett syndrome INSIGHT INTO AUTONOMIC DYSFUNCTIONS WITH NOVEL INTERVENTIONS: FOCUSING ON VASCULAR TONE AND BREATHING REGULATIONS" @default.
• W2340757448 created "2016-06-24" @default.
• W2340757448 creator A5002744113 @default.
• W2340757448 date "2016-01-01" @default.
• W2340757448 modified "2023-09-26" @default.
• W2340757448 title "Insight Into Autonomic Dysfunctions With Novel Interventions: Focusing On Vascular Tone And Breathing Regulations" @default.
• W2340757448 cites W122510374 @default.
• W2340757448 cites W131924336 @default.
• W2340757448 cites W1488916767 @default.
• W2340757448 cites W1493971026 @default.
• W2340757448 cites W1496311362 @default.
• W2340757448 cites W1496425517 @default.
• W2340757448 cites W1509696066 @default.
• W2340757448 cites W1522380633 @default.
• W2340757448 cites W1543332513 @default.
• W2340757448 cites W1546802604 @default.
• W2340757448 cites W1553579382 @default.
• W2340757448 cites W1559742681 @default.
• W2340757448 cites W1564500670 @default.
• W2340757448 cites W1572515149 @default.
• W2340757448 cites W1573273475 @default.
• W2340757448 cites W1574393133 @default.
• W2340757448 cites W1576009119 @default.
• W2340757448 cites W1580847222 @default.
• W2340757448 cites W1592649636 @default.
• W2340757448 cites W1597787921 @default.
• W2340757448 cites W1602588988 @default.
• W2340757448 cites W1607862065 @default.
• W2340757448 cites W1608418194 @default.
• W2340757448 cites W1619653867 @default.
• W2340757448 cites W1744173909 @default.
• W2340757448 cites W1750942102 @default.
• W2340757448 cites W1821002500 @default.
• W2340757448 cites W1849421930 @default.
• W2340757448 cites W1853270178 @default.
• W2340757448 cites W1919923011 @default.
• W2340757448 cites W1922287817 @default.
• W2340757448 cites W1929009802 @default.
• W2340757448 cites W1943576895 @default.
• W2340757448 cites W195660419 @default.
• W2340757448 cites W1963936141 @default.
• W2340757448 cites W1965111978 @default.
• W2340757448 cites W1965982887 @default.
• W2340757448 cites W1967180688 @default.
• W2340757448 cites W1967764176 @default.
• W2340757448 cites W1967914153 @default.
• W2340757448 cites W1970986757 @default.
• W2340757448 cites W1971290197 @default.
• W2340757448 cites W1972576960 @default.
• W2340757448 cites W1973309106 @default.
• W2340757448 cites W1973530752 @default.
• W2340757448 cites W1974841606 @default.
• W2340757448 cites W1975056548 @default.
• W2340757448 cites W1975499537 @default.
• W2340757448 cites W1975845294 @default.
• W2340757448 cites W1976148392 @default.
• W2340757448 cites W1976555160 @default.
• W2340757448 cites W1976953376 @default.
• W2340757448 cites W1977275820 @default.
• W2340757448 cites W1978039310 @default.
• W2340757448 cites W1978253480 @default.
• W2340757448 cites W1980129559 @default.
• W2340757448 cites W1980762198 @default.
• W2340757448 cites W1980981507 @default.
• W2340757448 cites W1981640212 @default.
• W2340757448 cites W1982580263 @default.
• W2340757448 cites W1984390450 @default.
• W2340757448 cites W1985214811 @default.
• W2340757448 cites W1985506911 @default.
• W2340757448 cites W1985991573 @default.
• W2340757448 cites W1986201961 @default.
• W2340757448 cites W1986383551 @default.
• W2340757448 cites W1987558313 @default.
• W2340757448 cites W1989832127 @default.
• W2340757448 cites W1989864699 @default.
• W2340757448 cites W1991061419 @default.
• W2340757448 cites W1991611683 @default.
• W2340757448 cites W1991818391 @default.
• W2340757448 cites W1992778391 @default.
• W2340757448 cites W1993913999 @default.
• W2340757448 cites W1993952575 @default.
• W2340757448 cites W1995682941 @default.
• W2340757448 cites W1996445930 @default.
• W2340757448 cites W1997011223 @default.
• W2340757448 cites W1997023449 @default.
• W2340757448 cites W1998123934 @default.
• W2340757448 cites W1999284097 @default.
• W2340757448 cites W1999507437 @default.
• W2340757448 cites W1999638490 @default.
• W2340757448 cites W2004472687 @default.
• W2340757448 cites W2004773897 @default.
• W2340757448 cites W2005614924 @default.
• W2340757448 cites W2005995704 @default.
• W2340757448 cites W2006439164 @default.
• W2340757448 cites W2006900645 @default.
• W2340757448 cites W2007018003 @default.
• W2340757448 cites W2007737411 @default.
• W2340757448 cites W2008684260 @default.
• W2340757448 cites W2008964449 @default.
• W2340757448 cites W2009192678 @default.

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