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- W2340758087 abstract "Introduction The concept of “bone graft expanders” has been popularised to increase the volume and biological activity of the implanted Material. HYPOTHESIS Orthoss® granules support exogenously seeded MSCs and attract neighbouring host MSCs. Methods In 3-D cultures’ Orthoss® granules were seeded with 2×10 5 bone marrow MSCs/granule and maintained in MSC expansion or differentiation media for 21 days. In homing experiments’ bone autografts were placed in close proximity to Orthoss®. Scaffold colonisation and MSC differentiation were assessed by confocal microscopy’ standard electron microscopy’ and energy-dispersive X-ray spectroscopy. Results Long-term incubation of MSC/scaffold resulted in formation of multiple cell-matrix layers lining the scaffold pores as well as outer surfaces. MSC differentiation to osteoblasts was evident as strong deposition of Calcium and Phosphorus was detected in both MSC expansion and osteogenic conditions. Cell egress experiments demonstrated the migration of cells from neighbouring autografts and their attachment and re-settlement on Orthoss®. Discussion & Conclusions Orthoss® scaffolds support MSC attachment’ growth and osteogenic differentiation whereas resident bone subpopulations can rapidly migrate towards’ attach’ and expand on them. These results indicate that Orthoss® can serve as a graft expander for repairing large bone defects in trauma patients." @default.
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- W2340758087 date "2013-04-01" @default.
- W2340758087 modified "2023-09-26" @default.
- W2340758087 title "BONE MARROW MULTIPOTENTIAL STROMAL CELL COLONISATION OF NATURAL BONE SUBSTITUTE ORTHOSS?-OSTEOCONDUCTIVITY? OSTEOINDUCTIVITY AND GRAFT EXPANDER POTENTIAL" @default.
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