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- W2340778883 abstract "[Purpose] The objective of this study was to evaluate the hepatoprotective effects of Hoveniae Semen Cum Fructus extract in ethanol induced hepatic damages. [Methods] Hepatic damages were induced by oral administration of ethanol and then Hoveniae Semen Cum Fructus extract was administered. [Results] Following Hoveniae Semen Cum Fructus extract administration, body and liver weights were increased, while aspartate aminotransferase, alanine aminotransferase, albumin, γ-glutamyl transferase, and triglyceride levels in the serum, triglyceride contents, tumor necrosis factor -α level, cytochrome (CY) P450 2E1 activity in the liver and mRNA expression of hepatic lipogenic genes, and Nitrotyrosine and 4-HNE-immunolabelled hepatocytes were decreased. However, mRNA expression of genes involved in fatty acid oxidation was increased. Also, as a protective mechanism for hepatic antioxidant defense systems, decreased liver MDA contents, increased glutathione contents, increased dismutase and catalase activities were observed when compared to the ethanol control. [Conclusion] Hoveniae Semen Cum Fructus extract favorably protected against liver damages, mediated by its potent anti-inflammatory and anti-steatosis properties through the augmentation of the hepatic antioxidant defense system by NF-E2-related factor-2 activation, and down-regulation of the mRNA expression of hepatic lipogenic genes or up-regulation of the mRNA expression of genes involved in fatty acid oxidation. Keywords: Hoveniae, hepatoprotective, mouse, Nrf2, antioxidant" @default.
- W2340778883 created "2016-06-24" @default.
- W2340778883 creator A5007318614 @default.
- W2340778883 creator A5035717231 @default.
- W2340778883 creator A5040225677 @default.
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- W2340778883 creator A5062184615 @default.
- W2340778883 creator A5081168723 @default.
- W2340778883 creator A5084423872 @default.
- W2340778883 date "2016-03-31" @default.
- W2340778883 modified "2023-10-17" @default.
- W2340778883 title "Hepatoprotective Effects of Hoveniae Semen Cum Fructus Extracts in ethanol intoxicated mice" @default.
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