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• W2340806795 abstract "To explore the association of serum Dickkopf-1 (DKK-1) levels with the development of ankylosing spondylitis (AS) and rheumatic arthritis (RA) in humans, databases including PubMed, EBSCO, Springerlink, Ovid, WANFANG and China National Knowledge Infrastructure (CNKI) were searched to identify relevant studies. On the basis of rigorous inclusion and exclusion criteria, case–control studies of the relationships between serum DKK-1 levels and AS and RA published before December 2014 were enrolled. Statistical analyses were performed using Comprehensive Meta-analysis 2.0 (CMA 2.0). Seven case–control trials with a total of 300 AS patients, 136 RA patients and 232 healthy controls were included in this study. Meta-analysis results revealed that DKK-1 serum levels were significantly higher in AS patients than in normal controls (standard mean differences (s.m.d.)=0.301, 95% confidence interval (CI)=0.094–0.507, P=0.004), whereas no significant difference in DKK-1 serum levels was observed between RA patients and healthy controls (s.m.d.=0.798, 95% CI=−2.166–3.763, P=0.598). Serum DKK-1 level may be closely related to the development of AS but not of RA. Elevated levels of a signaling protein in the blood may be a risk factor for ankylosing spondylitis and a biomarker for the disease. Ankylosing spondylitis is a chronic inflammation of the spine and other parts of the body and is believed to be an autoimmune disease. Conflicting reports have been published on a possible role for the signaling protein DKK-1 in ankylosing spondylitis and also in rheumatoid arthritis, another autoimmune condition. Researchers in China led by Xiong-Wen Wu of Huazhong University of Science & Technology conducted a statistical “meta-analysis” of international patient databases to try to clarify the issue. The results suggest that blood serum levels of DKK-1 are closely related to the development of ankylosing spondylitis, but not rheumatoid arthritis. This finding may lead to novel treatment options for ankylosing spondylitis." @default.
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• W2340806795 date "2016-04-22" @default.
• W2340806795 modified "2023-10-10" @default.
• W2340806795 title "Serum DKK-1 level in the development of ankylosing spondylitis and rheumatic arthritis: a meta-analysis" @default.
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• W2340806795 doi "https://doi.org/10.1038/emm.2016.12" @default.
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