Matches in SemOpenAlex for { <https://semopenalex.org/work/W2340821883> ?p ?o ?g. }
- W2340821883 endingPage "13" @default.
- W2340821883 startingPage "2909" @default.
- W2340821883 abstract "Colorectal cancer (CRC) results from the interaction between environmental exposures and genetic predisposition factors.A case control study was designed and to investigate the genotype frequencies of P53Arg72Pro polymorphism in Malaysian CRC patients and healthy controls and to determine the associated risk of this polymorphism with CRC predisposition.In this case-control study, peripheral blood samples of 202 sporadic CRC patients and 201 normal controls were collected, DNA extracted and genotyped using the polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) technique.Genotype analysis showed the frequency of homozygous variant (Pro/Pro) genotype (21%) to be significantly higher in cases compared to controls (13%), (p=0.013). On examining the association between variant genotypes and CRC risk, the Pro/Pro homozygous variant genotype showed significantly higher risk association with CRC susceptibility (OR: 2.047, CI: 1.063-4.044, p=0.033). When stratified according to age, we observed that, individuals aged above 50 years and carriers of pro/pro genotype had significantly higher risk with OR: 3.642, CI: 1.166-11.378, p=0.026.Our results suggest that the codon 72 SNP which results in amino acid substitution of Arginine to Proline in cell cycle regulatory gene P53, is associated with sporadic CRC risk and carriers of Pro/Pro genotype and more than 50 years old may have high susceptibility." @default.
- W2340821883 created "2016-06-24" @default.
- W2340821883 creator A5004112062 @default.
- W2340821883 creator A5022586934 @default.
- W2340821883 creator A5026754815 @default.
- W2340821883 creator A5045346904 @default.
- W2340821883 creator A5051356701 @default.
- W2340821883 creator A5085564626 @default.
- W2340821883 creator A5086894499 @default.
- W2340821883 date "2011-01-01" @default.
- W2340821883 modified "2023-09-23" @default.
- W2340821883 title "Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian population." @default.
- W2340821883 cites W15453418 @default.
- W2340821883 cites W1958660371 @default.
- W2340821883 cites W1967925876 @default.
- W2340821883 cites W1968006026 @default.
- W2340821883 cites W1980366769 @default.
- W2340821883 cites W1998559412 @default.
- W2340821883 cites W2008301561 @default.
- W2340821883 cites W2012900875 @default.
- W2340821883 cites W2015117947 @default.
- W2340821883 cites W2024323864 @default.
- W2340821883 cites W2029904263 @default.
- W2340821883 cites W2035746711 @default.
- W2340821883 cites W2037024229 @default.
- W2340821883 cites W2058586742 @default.
- W2340821883 cites W2066743464 @default.
- W2340821883 cites W2075230059 @default.
- W2340821883 cites W2079983085 @default.
- W2340821883 cites W2101943966 @default.
- W2340821883 cites W2102823703 @default.
- W2340821883 cites W2111005990 @default.
- W2340821883 cites W2122039687 @default.
- W2340821883 cites W2139288503 @default.
- W2340821883 cites W2152365979 @default.
- W2340821883 cites W2166875711 @default.
- W2340821883 cites W2169328504 @default.
- W2340821883 cites W2170534846 @default.
- W2340821883 cites W2467708251 @default.
- W2340821883 cites W3150748128 @default.
- W2340821883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22393962" @default.
- W2340821883 hasPublicationYear "2011" @default.
- W2340821883 type Work @default.
- W2340821883 sameAs 2340821883 @default.
- W2340821883 citedByCount "12" @default.
- W2340821883 countsByYear W23408218832013 @default.
- W2340821883 countsByYear W23408218832014 @default.
- W2340821883 countsByYear W23408218832015 @default.
- W2340821883 countsByYear W23408218832016 @default.
- W2340821883 countsByYear W23408218832017 @default.
- W2340821883 countsByYear W23408218832018 @default.
- W2340821883 countsByYear W23408218832019 @default.
- W2340821883 countsByYear W23408218832021 @default.
- W2340821883 crossrefType "journal-article" @default.
- W2340821883 hasAuthorship W2340821883A5004112062 @default.
- W2340821883 hasAuthorship W2340821883A5022586934 @default.
- W2340821883 hasAuthorship W2340821883A5026754815 @default.
- W2340821883 hasAuthorship W2340821883A5045346904 @default.
- W2340821883 hasAuthorship W2340821883A5051356701 @default.
- W2340821883 hasAuthorship W2340821883A5085564626 @default.
- W2340821883 hasAuthorship W2340821883A5086894499 @default.
- W2340821883 hasConcept C104317684 @default.
- W2340821883 hasConcept C121608353 @default.
- W2340821883 hasConcept C126322002 @default.
- W2340821883 hasConcept C135763542 @default.
- W2340821883 hasConcept C139275648 @default.
- W2340821883 hasConcept C143998085 @default.
- W2340821883 hasConcept C146304588 @default.
- W2340821883 hasConcept C153209595 @default.
- W2340821883 hasConcept C49105822 @default.
- W2340821883 hasConcept C526805850 @default.
- W2340821883 hasConcept C54355233 @default.
- W2340821883 hasConcept C67636389 @default.
- W2340821883 hasConcept C71924100 @default.
- W2340821883 hasConcept C86803240 @default.
- W2340821883 hasConcept C90924648 @default.
- W2340821883 hasConceptScore W2340821883C104317684 @default.
- W2340821883 hasConceptScore W2340821883C121608353 @default.
- W2340821883 hasConceptScore W2340821883C126322002 @default.
- W2340821883 hasConceptScore W2340821883C135763542 @default.
- W2340821883 hasConceptScore W2340821883C139275648 @default.
- W2340821883 hasConceptScore W2340821883C143998085 @default.
- W2340821883 hasConceptScore W2340821883C146304588 @default.
- W2340821883 hasConceptScore W2340821883C153209595 @default.
- W2340821883 hasConceptScore W2340821883C49105822 @default.
- W2340821883 hasConceptScore W2340821883C526805850 @default.
- W2340821883 hasConceptScore W2340821883C54355233 @default.
- W2340821883 hasConceptScore W2340821883C67636389 @default.
- W2340821883 hasConceptScore W2340821883C71924100 @default.
- W2340821883 hasConceptScore W2340821883C86803240 @default.
- W2340821883 hasConceptScore W2340821883C90924648 @default.
- W2340821883 hasIssue "11" @default.
- W2340821883 hasLocation W23408218831 @default.
- W2340821883 hasOpenAccess W2340821883 @default.
- W2340821883 hasPrimaryLocation W23408218831 @default.
- W2340821883 hasRelatedWork W1599582021 @default.
- W2340821883 hasRelatedWork W2010932598 @default.
- W2340821883 hasRelatedWork W2061753007 @default.