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- W2340833225 abstract "Crumbs 3 (CRB3) is a component of epithelial junctions, which has been implicated in apical-basal polarity, apical identity, apical stability, cell adhesion, and cell growth. CRB3 undergoes alternative splicing to yield two variants: CRB3a and CRB3b. Here, we describe novel data demonstrating that, as with previous studies on CRB3a, CRB3b also promotes the formation of tight junctions (TJs). However, significantly we demonstrate that the 4.1-ezrin-radixin-moesin-binding motif of CRB3b is required for CRB3b functionality and that ezrin binds to the FBM of CRB3b. Furthermore, we show that ezrin contributes to CRB3b functionality and the correct distribution of TJ proteins. We demonstrate that both CRB3 isoforms are required for the production of functionally mature TJs and also the localization of ezrin to the plasma membrane. Finally, we demonstrate that reduced CRB3b expression in head and neck squamous cell carcinoma (HNSCC) correlates with cytoplasmic ezrin, a biomarker for aggressive disease, and shows evidence that while CRB3a expression has no effect, low CRB3b and high cytoplasmic ezrin expression combined may be prognostic for HNSCC." @default.
- W2340833225 created "2016-06-24" @default.
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- W2340833225 date "2016-10-01" @default.
- W2340833225 modified "2023-10-16" @default.
- W2340833225 title "Crumbs 3b promotes tight junctions in an ezrin-dependent manner in mammalian cells" @default.
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- W2340833225 cites W1975083495 @default.
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- W2340833225 cites W1980547384 @default.
- W2340833225 cites W1982573961 @default.
- W2340833225 cites W1984768151 @default.
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- W2340833225 cites W1991313260 @default.
- W2340833225 cites W1991469068 @default.
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- W2340833225 cites W2040509817 @default.
- W2340833225 cites W2046786425 @default.
- W2340833225 cites W2050944592 @default.
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- W2340833225 doi "https://doi.org/10.1093/jmcb/mjw020" @default.
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- W2340833225 hasPublicationYear "2016" @default.
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