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- W2340833512 abstract "Carbonic anhydrase (CA) is being used as a model for matrix metalloproteinases (MMPs). CA is a more ubiquitous protein that binds zinc in the same manner as MMPs, His3(OH). Current MMP inhibitors target both unregulated and normal functioning MMPs at the catalytic Zn(II) site, but show minimal specificity and high toxicity. A new class of inhibitor building blocks are being evaluated as potential MMP inhibitor scaffolds, based on their interactions with Zn- and Co- containing CA." @default.
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- W2340833512 date "2016-02-01" @default.
- W2340833512 modified "2023-09-26" @default.
- W2340833512 title "Modeling Matrix Metalloproteinase Inhibition with Carbonic Anhydrase" @default.
- W2340833512 doi "https://doi.org/10.1016/j.bpj.2015.11.863" @default.
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