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- W2340871616 abstract "Lighter is a fast and memory-ecient tool for correcting sequencing errors in high-throughput sequencing datasets. Lighter avoids counting k-mers in the sequencing reads. Instead, it uses a pair of Bloom lters, one populated with a sample of the input k-mers and the other populated with k-mers likely to be correct based on a simple test. As long as the sampling fraction is adjusted in inverse proportion to the depth of sequencing, the Bloom lter size can be held constant while maintaining near-constant accuracy. Lighter is easily applied to very large sequencing datasets. It is parallelized, uses no secondary storage, and is both faster and more memory-ecient than competing approaches while achieving comparable accuracy. Lighter is free open source software available from https://github.com/mourisl/Lighter/." @default.
- W2340871616 created "2016-06-24" @default.
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- W2340871616 date "2014-01-01" @default.
- W2340871616 modified "2023-09-27" @default.
- W2340871616 title "Lighter: fast and memory-ecient error correction without counting" @default.
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