Matches in SemOpenAlex for { <https://semopenalex.org/work/W234088308> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W234088308 endingPage "13" @default.
- W234088308 startingPage "106" @default.
- W234088308 abstract "Using allantoin (ATN) as a marker for reactive oxygen species (ROS), oxidative stress during antituberculous (anti-TB) therapy was compared in 10 young and 9 elderly patients. Before treatment, ATN plasma concentrations in patients were similar to that of volunteers. Administration of a combination of isoniazid (INH), rifampicin (RIF) and pyrazinamide (PZA) increased plasma ATN in both groups of patients. ATN concentrations (M +/- SE) at six hours were higher (P < 0.05) in elderly than in young patients on day one, 8.22 +/- 1.50 vs 1.89 +/- 0.98 microgram/mL); day 30, (5.85 +/- 0.82 vs 0.87 +/- 0.57 microgram/mL; and day 90, (4.84 +/- 1.24 vs 0.52 +/- 0.50 microgram/mL). Because total amount of ATN excreted was similar in both groups on the three occasions, more ATN was formed in elderly than young patients. In conclusion, there was more oxidative stress in elderly than young patients. It is thereby suggested that Anti-TB drugs induce formation of ROS and elderly patients are at a greater risk of toxicity probably because of poor antioxidant mechanisms." @default.
- W234088308 created "2016-06-24" @default.
- W234088308 creator A5016757946 @default.
- W234088308 creator A5026798102 @default.
- W234088308 creator A5035670302 @default.
- W234088308 date "1995-06-01" @default.
- W234088308 modified "2023-09-23" @default.
- W234088308 title "Oxidative stress during antituberculous therapy in young and elderly patients." @default.
- W234088308 cites W112512152 @default.
- W234088308 cites W1907068960 @default.
- W234088308 cites W1998019646 @default.
- W234088308 cites W2002373438 @default.
- W234088308 cites W2025372788 @default.
- W234088308 cites W2078612853 @default.
- W234088308 cites W2324148764 @default.
- W234088308 cites W34092490 @default.
- W234088308 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7546339" @default.
- W234088308 hasPublicationYear "1995" @default.
- W234088308 type Work @default.
- W234088308 sameAs 234088308 @default.
- W234088308 citedByCount "11" @default.
- W234088308 countsByYear W2340883082012 @default.
- W234088308 countsByYear W2340883082013 @default.
- W234088308 countsByYear W2340883082014 @default.
- W234088308 countsByYear W2340883082015 @default.
- W234088308 countsByYear W2340883082016 @default.
- W234088308 countsByYear W2340883082017 @default.
- W234088308 countsByYear W2340883082019 @default.
- W234088308 crossrefType "journal-article" @default.
- W234088308 hasAuthorship W234088308A5016757946 @default.
- W234088308 hasAuthorship W234088308A5026798102 @default.
- W234088308 hasAuthorship W234088308A5035670302 @default.
- W234088308 hasConcept C126322002 @default.
- W234088308 hasConcept C142724271 @default.
- W234088308 hasConcept C185592680 @default.
- W234088308 hasConcept C202751555 @default.
- W234088308 hasConcept C2776073210 @default.
- W234088308 hasConcept C2776151105 @default.
- W234088308 hasConcept C2776967927 @default.
- W234088308 hasConcept C2778607973 @default.
- W234088308 hasConcept C2780459521 @default.
- W234088308 hasConcept C2781069245 @default.
- W234088308 hasConcept C29730261 @default.
- W234088308 hasConcept C51296783 @default.
- W234088308 hasConcept C55493867 @default.
- W234088308 hasConcept C71924100 @default.
- W234088308 hasConcept C90924648 @default.
- W234088308 hasConcept C98274493 @default.
- W234088308 hasConceptScore W234088308C126322002 @default.
- W234088308 hasConceptScore W234088308C142724271 @default.
- W234088308 hasConceptScore W234088308C185592680 @default.
- W234088308 hasConceptScore W234088308C202751555 @default.
- W234088308 hasConceptScore W234088308C2776073210 @default.
- W234088308 hasConceptScore W234088308C2776151105 @default.
- W234088308 hasConceptScore W234088308C2776967927 @default.
- W234088308 hasConceptScore W234088308C2778607973 @default.
- W234088308 hasConceptScore W234088308C2780459521 @default.
- W234088308 hasConceptScore W234088308C2781069245 @default.
- W234088308 hasConceptScore W234088308C29730261 @default.
- W234088308 hasConceptScore W234088308C51296783 @default.
- W234088308 hasConceptScore W234088308C55493867 @default.
- W234088308 hasConceptScore W234088308C71924100 @default.
- W234088308 hasConceptScore W234088308C90924648 @default.
- W234088308 hasConceptScore W234088308C98274493 @default.
- W234088308 hasIssue "2" @default.
- W234088308 hasLocation W2340883081 @default.
- W234088308 hasOpenAccess W234088308 @default.
- W234088308 hasPrimaryLocation W2340883081 @default.
- W234088308 hasRelatedWork W1980640494 @default.
- W234088308 hasRelatedWork W2007242239 @default.
- W234088308 hasRelatedWork W2112727823 @default.
- W234088308 hasRelatedWork W2145780375 @default.
- W234088308 hasRelatedWork W2315742119 @default.
- W234088308 hasRelatedWork W234088308 @default.
- W234088308 hasRelatedWork W2365555518 @default.
- W234088308 hasRelatedWork W2412864285 @default.
- W234088308 hasRelatedWork W68829940 @default.
- W234088308 hasRelatedWork W2785926487 @default.
- W234088308 hasVolume "8" @default.
- W234088308 isParatext "false" @default.
- W234088308 isRetracted "false" @default.
- W234088308 magId "234088308" @default.
- W234088308 workType "article" @default.