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• W2340904674 abstract "While up to 45% of individuals with intellectual and developmental disabilities (IDD) have a comorbid psychiatric disorder, and antipsychotics are commonly prescribed, gender differences in the safety of antipsychotics have rarely been studied in this population.To compare men and women with IDD on medical outcomes after antipsychotic initiation.Our population-based study in Ontario, Canada, compared 1457 women and 1951 men with IDD newly initiating antipsychotic medication on risk for diabetes mellitus, hypertension, venous thromboembolism, myocardial infarction, stroke and death, with up to 4 years of follow-up.Women were older and more medically complex at baseline. Women had higher risks for venous thromboembolism (HR 1.72, 95% CI 1.15-2.59) and death (HR 1.46, 95% CI 1.02-2.10) in crude analyses; but only thromboembolism risk was greater for women after covariate adjustment (aHR 1.58, 95% CI 1.05-2.38).Gender should be considered in decision-making around antipsychotic medications for individuals with IDD.None.© The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence." @default.
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• W2340904674 date "2016-03-01" @default.
• W2340904674 modified "2023-10-16" @default.
• W2340904674 title "Morbidity and mortality of women and men with intellectual and developmental disabilities newly initiating antipsychotic drugs" @default.
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• W2340904674 doi "https://doi.org/10.1192/bjpo.bp.116.002691" @default.
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