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• W2340907519 abstract "Event Abstract Back to Event Inhibition of RGD-modified composite nerve conduit on traumatic neuroma formation Yixia Yin1*, Qiongjiao Yan1*, Honglian Dai1*, Jiling Yi1*, Tong Qiu1, Xinyu Wang1* and Shipu Li1* 1 Wuhan University of Technology, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, China Peripheral nerve injury is the common cause that leads to disability. Large nerve defect and traumatic neuroma are two main bottleneck problems during repairing after peripheral nerve injury. So far, the mechanism of neuroma development and progression are still unclear, and there is very limited research on neuroma inhibition with nerve conduit. Our group previously found that a PDLLA/PRGD/β-TCP composite conduit had beneficial effect on nerve regeneration, and no obvious neuroma formation was found in around 300 experimental animals. The main mechanism of neuroma formation is based on excessively sedimentary collagen proliferation. We hypothesize that PDLLA/PRGD/β-TCP composite have the effect on the neural scar formation-related cytokines such as NGF, IFN-γ etc., matrix metallo-proteinases, gene expression and protein level of collagen. The effect of the conduit on neural scar distribution and scar ratio, nerve function recovery, structure of regenerated myelin sheath have been studied. In vitro test, PRGD/PDLLA/β-TCP membranes showed better cytocompatibility with Schwann cells. Testing in vivo demonstrated that PRGD/PDLLA/β-TCP conduits can effectively promote axonal regeneration of 10mm rat sciatic nerve defect, which is close to the success of autograft. After an observation period of 1 month, PRGD/PDLLA/β-TCP conduit-implanted showed no neuroma and significantly improving on the neurophysiological and neuropathological levels compared with the PDLLA conduit as control group. The microenvironment of the inner conduit, containing an appropriate concentration of calcium ion, growth factors and immunologic factors, played an important role in the inhibition of neuroma formation. The neural scar distribution is perineural scarring and the scar ratio is lower than the control of PDLLA group . The study revealed that PRGD/PDLLA/β-TCP conduits promoted nerve regeneration and inhibits neuroma formation. It is going to provide experimental basis for future studies in nerve conduits for inhibition of neuroma formation and promoting long-distance nerve regeneration as well as the clinical therapy for neuroma. National Basic Research Program of China (973 Program, No. 2011CB606205) and National Natural Science Foundation of China (No. 51403168) Keywords: Mechanism, in vivo, biomaterial, Tissue Regeneration Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Biomaterials in nerve regeneration Citation: Yin Y, Yan Q, Dai H, Yi J, Qiu T, Wang X and Li S (2016). Inhibition of RGD-modified composite nerve conduit on traumatic neuroma formation. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.01197 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. * Correspondence: Dr. Yixia Yin, Wuhan University of Technology, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan, China, Email1 Dr. Qiongjiao Yan, Wuhan University of Technology, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan, China, yanqiongjiao2@126.com Dr. Honglian Dai, Wuhan University of Technology, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan, China, daihonglian@whut.edu.cn Dr. Jiling Yi, Wuhan University of Technology, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan, China, Email2 Dr. Xinyu Wang, Wuhan University of Technology, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan, China, Email3 Dr. Shipu Li, Wuhan University of Technology, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan, China, liship46@126.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Yixia Yin Qiongjiao Yan Honglian Dai Jiling Yi Tong Qiu Xinyu Wang Shipu Li Google Yixia Yin Qiongjiao Yan Honglian Dai Jiling Yi Tong Qiu Xinyu Wang Shipu Li Google Scholar Yixia Yin Qiongjiao Yan Honglian Dai Jiling Yi Tong Qiu Xinyu Wang Shipu Li PubMed Yixia Yin Qiongjiao Yan Honglian Dai Jiling Yi Tong Qiu Xinyu Wang Shipu Li Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2340907519 title "Inhibition of RGD-modified composite nerve conduit on traumatic neuroma formation" @default.
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