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• W2340932744 abstract "// Chuannan Fan 1, * , Yancheng Lin 1, * , Yubin Mao 1, 2, * , Zhengjie Huang 3, * , Allan Yi Liu 1 , Handong Ma 1 , Donghong Yu 1 , Alaiyi Maitikabili 1 , Hongjun Xiao 1 , Chuankai Zhang 3 , Fan Liu 2 , Qi Luo 3 , Gaoliang Ouyang 1, 4 1 State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, China 2 Medical College, Xiamen University, Xiamen, China 3 Department of Surgical Oncology, First Affiliated Hospital of Xiamen University, Xiamen, China 4 Engineering Research Centre of Molecular Diagnostics, Ministry of Education, School of Life Sciences, Xiamen University, Xiamen, China * These authors contributed equally to this work Correspondence to: Gaoliang Ouyang, e-mail: oygldz@xmu.edu.cn Keywords: miR-543, colorectal cancer, metastasis, proliferation, microRNA Received: September 23, 2015      Accepted: February 23, 2016      Published: March 08, 2016 ABSTRACT miR-543 has been implicated as having a critical role in the development of breast cancer, endometrial cancer and hepatocellular carcinoma. However, the exact clinical significance and biological functions of miR-543 in colorectal cancer (CRC) remain unclear. Here, we found that miR-543 expression significantly downregulated in tumors from patients with CRC, APC Min mice and a mouse model of colitis-associated colon cancer. miR-543 level was inversely correlated with the metastatic status of patients with CRC and the metastatic potential of CRC cell lines. Moreover, ectopic expression of miR-543 inhibited the proliferation and metastasis of CRC cells in vitro and in vivo by targeting KRAS, MTA1 and HMGA2. Conversely, miR-543 knockdown promoted the proliferation, migration and invasion of CRC cells in vitro and augmented tumor growth and metastasis in vivo . Furthermore, we found that miR-543 expression was negatively correlated with the levels of KRAS, MTA1 and HMGA2 in clinical samples. Collectively, these data show that miR-543 inhibits the proliferation and metastasis of CRC cells by targeting KRAS, MTA1 and HMGA2. Our study highlights a pivotal role for miR-543 as a suppressor in the regulation of CRC growth and metastasis and suggests that miR-543 may serve as a novel diagnostic and prognostic biomarker for CRC metastasis." @default.
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• W2340932744 date "2016-03-08" @default.
• W2340932744 modified "2023-10-09" @default.
• W2340932744 title "MicroRNA-543 suppresses colorectal cancer growth and metastasis by targeting KRAS, MTA1 and HMGA2" @default.
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• W2340932744 doi "https://doi.org/10.18632/oncotarget.7989" @default.
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