Matches in SemOpenAlex for { <https://semopenalex.org/work/W2340956968> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2340956968 endingPage "473" @default.
- W2340956968 startingPage "468" @default.
- W2340956968 abstract "Patients with acute liver failure (ALF) have substantial alterations in their hemostatic system. Since an international normalized ratio of ≥ 1.5 is part of the definition of the syndrome, it has long been believed that patients with ALF had a hemostasis-related bleeding tendency. Recent data, however, show that spontaneous bleeding in ALF is rare. In addition, thrombotic complications may be more common than spontaneous bleeding complications. Laboratory studies have suggested that patients with ALF may be in hemostatic balance as a result of a commensurate decline in pro- and anti-hemostatic factors. The unstable nature of the hemostatic balance in ALF may explain the occurrence of both bleeding and thrombotic complications. The hemostatic profile of patients with ALF includes hypercoagulable features, including von Willebrand factor/a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13 unbalance, elevated levels of highly procoagulant, platelet-derived microparticles, and a profound hypofibrinolytic status. These hypercoagulable features may contribute to systemic thrombotic complications, but may also drive intrahepatic clot formation. Studies in experimental animal models of ALF have demonstrated that intrahepatic clot formation contributes to disease progression. The clinical consequences of these new insights in the hemostatic system of patients with ALF will be discussed in this review." @default.
- W2340956968 created "2016-06-24" @default.
- W2340956968 creator A5053115833 @default.
- W2340956968 creator A5074302578 @default.
- W2340956968 date "2015-06-06" @default.
- W2340956968 modified "2023-10-03" @default.
- W2340956968 title "Rebalanced Hemostasis in Patients with Acute Liver Failure" @default.
- W2340956968 doi "https://doi.org/10.1055/s-0035-1550430" @default.
- W2340956968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26049071" @default.
- W2340956968 hasPublicationYear "2015" @default.
- W2340956968 type Work @default.
- W2340956968 sameAs 2340956968 @default.
- W2340956968 citedByCount "71" @default.
- W2340956968 countsByYear W23409569682015 @default.
- W2340956968 countsByYear W23409569682016 @default.
- W2340956968 countsByYear W23409569682017 @default.
- W2340956968 countsByYear W23409569682018 @default.
- W2340956968 countsByYear W23409569682019 @default.
- W2340956968 countsByYear W23409569682020 @default.
- W2340956968 countsByYear W23409569682021 @default.
- W2340956968 countsByYear W23409569682022 @default.
- W2340956968 countsByYear W23409569682023 @default.
- W2340956968 crossrefType "journal-article" @default.
- W2340956968 hasAuthorship W2340956968A5053115833 @default.
- W2340956968 hasAuthorship W2340956968A5074302578 @default.
- W2340956968 hasConcept C109523444 @default.
- W2340956968 hasConcept C126322002 @default.
- W2340956968 hasConcept C167814343 @default.
- W2340956968 hasConcept C203014093 @default.
- W2340956968 hasConcept C2778259572 @default.
- W2340956968 hasConcept C2778589496 @default.
- W2340956968 hasConcept C2778780528 @default.
- W2340956968 hasConcept C2779394231 @default.
- W2340956968 hasConcept C55728118 @default.
- W2340956968 hasConcept C71924100 @default.
- W2340956968 hasConcept C89560881 @default.
- W2340956968 hasConcept C90924648 @default.
- W2340956968 hasConceptScore W2340956968C109523444 @default.
- W2340956968 hasConceptScore W2340956968C126322002 @default.
- W2340956968 hasConceptScore W2340956968C167814343 @default.
- W2340956968 hasConceptScore W2340956968C203014093 @default.
- W2340956968 hasConceptScore W2340956968C2778259572 @default.
- W2340956968 hasConceptScore W2340956968C2778589496 @default.
- W2340956968 hasConceptScore W2340956968C2778780528 @default.
- W2340956968 hasConceptScore W2340956968C2779394231 @default.
- W2340956968 hasConceptScore W2340956968C55728118 @default.
- W2340956968 hasConceptScore W2340956968C71924100 @default.
- W2340956968 hasConceptScore W2340956968C89560881 @default.
- W2340956968 hasConceptScore W2340956968C90924648 @default.
- W2340956968 hasIssue "05" @default.
- W2340956968 hasLocation W23409569681 @default.
- W2340956968 hasLocation W23409569682 @default.
- W2340956968 hasOpenAccess W2340956968 @default.
- W2340956968 hasPrimaryLocation W23409569681 @default.
- W2340956968 hasRelatedWork W184289008 @default.
- W2340956968 hasRelatedWork W2096395497 @default.
- W2340956968 hasRelatedWork W2143874699 @default.
- W2340956968 hasRelatedWork W2232953465 @default.
- W2340956968 hasRelatedWork W2340956968 @default.
- W2340956968 hasRelatedWork W2546730454 @default.
- W2340956968 hasRelatedWork W2626271870 @default.
- W2340956968 hasRelatedWork W2889857566 @default.
- W2340956968 hasRelatedWork W3199761821 @default.
- W2340956968 hasRelatedWork W4234373395 @default.
- W2340956968 hasVolume "41" @default.
- W2340956968 isParatext "false" @default.
- W2340956968 isRetracted "false" @default.
- W2340956968 magId "2340956968" @default.
- W2340956968 workType "article" @default.