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• W2340988437 abstract "We developed quantitative assays to test the hypothesis that the N-DRC is required for integrity of the ciliary axoneme. We examined reactivated motility of demembranated drc cells, commonly termed reactivated cell models. ATP-induced reactivation of wild-type cells resulted in the forward swimming of ∼90% of cell models. ATP-induced reactivation failed in a subset of drc cell models, despite forward motility in live drc cells. Dark-field light microscopic observations of drc cell models revealed various degrees of axonemal splaying. In contrast, >98% of axonemes from wild-type reactivated cell models remained intact. The sup-pf4 and drc3 mutants, unlike other drc mutants, retain most of the N-DRC linker that interconnects outer doublet microtubules. Reactivated sup-pf4 and drc3 cell models displayed nearly wild-type levels of forward motility. Thus, the N-DRC linker is required for axonemal integrity. We also examined reactivated motility and axoneme integrity in mutants defective in tubulin polyglutamylation. ATP-induced reactivation resulted in forward swimming of >75% of tpg cell models. Analysis of double mutants defective in tubulin polyglutamylation and different regions of the N-DRC indicate B-tubule polyglutamylation and the distal lobe of the linker region are both important for axonemal integrity and normal N-DRC function. © 2016 Wiley Periodicals, Inc." @default.
• W2340988437 created "2016-06-24" @default.
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• W2340988437 date "2016-06-01" @default.
• W2340988437 modified "2023-10-17" @default.
• W2340988437 title "The nexin link and B-tubule glutamylation maintain the alignment of outer doublets in the ciliary axoneme" @default.
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• W2340988437 doi "https://doi.org/10.1002/cm.21301" @default.
• W2340988437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5033114" @default.
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