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- W2341000930 abstract "The canonical Wnt/β-catenin signaling pathway plays multiple roles during Xenopus gastrulation, including posteriorization of the neural plate, patterning of the mesoderm, and induction of the neural crest. Wnt signaling stabilizes β-catenin, which then activates target genes. However, few targets of this signaling pathway that mediate early developmental processes are known. Here we sought to identify transcriptional targets of the Wnt/β-catenin signaling pathway using a genome-wide approach. We selected putative targets using the criteria of reduced expression upon zygotic Wnt knockdown, β-catenin binding within 50kb of the gene, and expression in tissues that receive Wnt signaling. Using these criteria, we found 21 novel direct transcriptional targets of Wnt/β-catenin signaling during gastrulation and in addition have identified putative regulatory elements for further characterization in future studies." @default.
- W2341000930 created "2016-06-24" @default.
- W2341000930 creator A5002777290 @default.
- W2341000930 creator A5065805206 @default.
- W2341000930 date "2017-06-01" @default.
- W2341000930 modified "2023-10-05" @default.
- W2341000930 title "Genome-wide identification of Wnt/β-catenin transcriptional targets during Xenopus gastrulation" @default.
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- W2341000930 doi "https://doi.org/10.1016/j.ydbio.2016.03.021" @default.
- W2341000930 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6288011" @default.
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