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- W2341014162 abstract "The current situation of Alzheimer’s disease (AD) management is deeply disappointing because there is no way to prevent or cure the disease, and the medicines on the market are only able to provide moderate symptomatic delay. It is also very frustrating that the mechanisms underlying AD’s evolution remain largely unknown and the pace of developing diseasemodifying drugs (DMDs) is extremely slow. According to the Alzheimer’s Association, an estimated 5.4 million Americans have this progressive, degenerative and irreversible brain disorder, and the number will exponentially increase if no new therapeutic approaches are developed. The disease has also put a huge economic burden on society with an annual cost of approximately US$180 billion for patient care in the USA alone. Obviously, there is an urgent and unmet need for rapidly developing new" @default.
- W2341014162 created "2016-06-24" @default.
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- W2341014162 date "2012-01-01" @default.
- W2341014162 modified "2023-09-27" @default.
- W2341014162 title "Iron chelation and nanoparticle target delivery in the development of new multifunctional disease-modifying drugs for Alzheimer's disease …our studies show that chelator-nanoparticles have the potential to act as multifunctional disease-modifying drugs with respect to excess metal depletion, oxidative damage inhibition, Ab aggregation and toxicity prevention." @default.
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