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- W2341036619 abstract "Activation of the yeast cell wall integrity (CWI) pathway induces an adaptive transcriptional program largely dependent on the transcription factor Rlm1 and the MAPK Slt2. Upon cell wall stress, the transcription factor Rlm1 is highly recruited to the promoters of RLM1 and SLT2 and exerts positive feedback mechanisms on the expression of both genes. Activation of the MAPK Slt2 by cell wall stress is not impaired in strains with individual blockade of any of the two feedbacks. Abrogation of the autoregulatory feedback mechanism on RLM1 severely affects the transcriptional response elicited by activation of the CWI pathway. In contrast, positive trans-acting feedback mechanism exerted by Rlm1 on SLT2 also regulate CWI output responses but to a lesser extent. Therefore, a complete CWI transcriptional response requires not only phosphorylation of Rlm1 by Slt2 but also the concurrence of SLT2 and RLM1 mediated positive feedbacks; sustaining patterns of gene expression are mainly achieved by positive autoregulatory circuits based on the transcriptional activation of Rlm1." @default.
- W2341036619 created "2016-06-24" @default.
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- W2341036619 date "2016-01-01" @default.
- W2341036619 modified "2023-10-08" @default.
- W2341036619 title "Rlm1 mediates a positive autoregulatory transcriptional feedback essential for Slt2 MAPK dependent gene expression" @default.
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- W2341036619 doi "https://doi.org/10.1242/jcs.180190" @default.
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