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• W2341116128 abstract "Ageing process was initially thought of ‘as a proper and inevitable part of life’ but today it is widely considered to be a disease or ailment, a process that can be treated. Ageing can occur due to damage to DNA caused by high-energy particles, such as UV light and X-rays, viruses, free radicals, sugar aldehydes, or other chemicals in the body, inappropriate activation or deactivation of genes, faulty duplication of DNA during cell division, accumulation of bulky molecular debris, such as amyloid protein and lipofuscin and damaged structural molecules, especially proteins, inside and between the cells of body tissues. Ageing is a syndrome of changes that is deleterious, progressive, universal and thus far irreversible. Diseases of old age (diseases which increase in frequency with age, such as arthritis, osteoporosis, heart disease, cancer etc. are often distinguished from ageing per se. But even if the ageing process is distinct from the diseases of aging, it is nonetheless true that the damage associated with the aging process increases the probability that diseases of old age will occur. Ageing have led to the two major classifications programmed ageing and wear and tear aging. Programmed ageing would be aging due to something inside an organism's control mechanisms that forces elderliness and deterioration. By contrast, aging due to wear and tear is not the result of any specific controlling program, but is the effect of the sum effect of many kinds of environmental assaults ‐ that is damage due to radiation, chemical toxins, metal ions, free-radicals, hydrolysis, glycation, disulfide-bond cross-linking, etc. Such damage can affect genes, proteins, cell membranes, enzyme function, blood vessels, etc.1 Free radical theory suggests that there may be a gradual accumulation of free radicals in cells with time and that, as they exceed threshold concentration, they may contribute to change, commonly associated with ageing. These free radicals are self-propagating and as the number of free radicals increases, their potential to cause cellular damage also increase. Aerobe living is consequently connected with permanent oxidation of cellular proteins. Free radicals and other oxidation damage the normal intracellular pool. The evidence of oxidative and other damage to these non-DNA components is overwhelming. The problem of ‘rejuvenation’ (removal of the damaged material) is wellrecognized by researchers in the field, but very little research has been published upto now dealing with a possible mechanism of this rejuvenation process. The repair processes include: protein degradation in the proteosomal pathway, nonsense-mediated mRNA decay, autophagy, mitophagy and others. Therefore, the prevention of accumulation of oxidized cellular proteins is one of the major functions of the proteolytic complex, the proteosome. Proteosome is the major protease that is able to recognize and degrade oxidized proteins.2" @default.
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• W2341116128 date "2008-08-01" @default.
• W2341116128 modified "2023-09-24" @default.
• W2341116128 title "Ageing and health: free radicals and oxidative stress." @default.
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