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- W2341116179 abstract "Introduction: Gallbladder carcinoma is a rare but aggressive malignancy with increasing prevalence. This analysis reviews thirty-five cases of gallbladder cancer in five years and outcomes within this unusually large number of patients referred to three tertiary hospitals within a rural community (estimated total population 250,000). Methods: A retrospective review of patients with pathologically identified gallbladder carcinoma, treated within 2006–2012 was preformed. Of the 14 male and 21 female patients, the average age and ASA class were 67.88 ± 11.88 years old and 3.17 ± 0.61. Overall survival was 25.02 ± 25.17 months. Mean survival decreased with increasing stage. Results: There was no statistically significant association between tumor differentiation and patient survival. Pathology containing lymphovascular invasion had significantly decreased survival. There was no statistically significant increase in survival rate for those undergoing radical resection/re-resection for the entire cohort; however, for patients with Stage II and Stage III disease that underwent radical resection there was a statistically significant increase in survival. Of note, administration of chemotherapy did not confer an overall survival benefit for patients as a whole. Patients who received radiation therapy did not have an increased overall survival rate. Treatment by a hepato-pancreato-biliary surgeon conferred a statistically significant increase in survival. Conclusion: An increased incidence of gallbladder carcinoma within our rural patient population far exceeds current SEER data (thirty-five patients in five years). Stage II and Stage III gallbladder carcinoma receive the largest benefit from R0 resections. The survival benefit of chemotherapy administration in our stage IV gallbladder carcinoma patients deserves further investigation." @default.
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- W2341116179 date "2016-04-01" @default.
- W2341116179 modified "2023-10-16" @default.
- W2341116179 title "Incidence and outcomes of gallbladder cancer treatment in a rural patient population" @default.
- W2341116179 doi "https://doi.org/10.1016/j.hpb.2016.03.255" @default.
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