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- W2341198483 abstract "Mice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice. Since monoamines in these areas are critically involved in a variety of behaviors, we examined learning and memory (using emo- tional and motor tasks) in MAOA mutant mice. The MAOA- deficient mice exhibited significantly enhanced classical fear conditioning (freezing to both tone and contextual stimuli) and step-down inhibitory avoidance learning. In contrast, eyeblink conditioning was normal in these mutant mice. The female MAOA-deficient mice also displayed normal species- typicalmaternalbehaviors(nesting,nursing,andpupretriev- al). These results suggest that chronic elevations of mono- amines, due to a deletion of the gene encoding MAOA, lead to selective alterations in emotional behavior." @default.
- W2341198483 created "2016-06-24" @default.
- W2341198483 creator A5056121120 @default.
- W2341198483 date "1997-01-01" @default.
- W2341198483 modified "2023-09-27" @default.
- W2341198483 title "Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice (amygdalaynorepinephrineyserotoninycerebellumymutant mice) JEANSOKJ. KIM*† ,J EANC. SHIH‡ ,K EVINCHEN‡ ,L U CHEN*, SHAOWENBAO*, STEPHENMAREN§, STEPHANG. ANAGNOSTARAS§ ,M ICHAELS. FANSELOW§ ,E DWARDDEMAEYER¶ ,I SABELLESEIF¶," @default.
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