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- W2341209236 abstract "Segments of proximal duodenum from Rana cates beiana, stripped of external muscle and mounted as a tube in a glass chamber, alkalinized the luminal side bathing solution at a rate of 1.70 ± 0.16 /-tEq / cm . h (n = IB, gross surface area -1.5 cm 2 /c m). A single change of the serosal-side bathing solution for fresh solution reduced the rate of titratable alkaline secretion, which achieved a new steady state after 45 min amounting to 66% ± 2% of the initial rate; transmucosal potential difference (lumen negative) fell from 10 .6 ± 1.2 to B.B ± 1.1 mY. Concentrations of E-type prostaglandins in the serosal-side solution measured by radioimmunoassay were B.5 nM (3 ng/ ml) before, 0.17 nM 5 min after, and 1.7 nM 90 min after the solution change (n = B). Reapplication of the original bathing solution 90 min after the initial change reestablished original secretory rate and potential difference . The increases in alkaline secre tion and potential difference were comparable in magnitude and profile to those induced by serosal administration of 10 nM prostaglandin E2 . Addition of the metabolic inhibitor 2 ,4-dinitrophenol (100 /-tM, serosal side) reduced basal alkaline secreti on to 30% ± 7% of the initial rate and abolished the potential difference (n = B). These data demonstrate that endogenous prostaglandin E production by an isolated preparation of amphibian duodenum ac counts for a proportion of alkaline secretion that is equivalent to 50% of metabolism-dependent basal secretion." @default.
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- W2341209236 date "1985-01-01" @default.
- W2341209236 modified "2023-09-23" @default.
- W2341209236 title "Endogenous E-Type Prostaglandins in" @default.
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