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- W2341325304 abstract "To the Editor: Adult-onset Still’s disease (AOSD) is a rare systemic inflammatory disease characterized by arthralgias, transient cutaneous eruption, and high fluctuating fever1. No pathognomonic biological marker has yet been identified, making diagnosis difficult.Recent pathophysiological findings showed thatAOSD is characterized by a particular cytokine profile, suggesting implication of Th1 immune response. The overwhelming implication of interleukin 1 (IL-1) in the systemic inflammatory reaction seen during the course of AOSD has justified the administration of agents blocking IL-1 receptor (anakinra), which gave some good results3,4. We describe a case of AOSD with an activated macrophage syndrome that responded to anakinra.…" @default.
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- W2341325304 date "2008-12-01" @default.
- W2341325304 modified "2023-09-25" @default.
- W2341325304 title "Blockade of Interleukin 1 Receptor in Still’s Disease Affects Activation of Peripheral T-Lymphocytes" @default.
- W2341325304 doi "https://doi.org/10.3899/jrheum.080150" @default.
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