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- W2341335814 abstract "Hydroxy daunorubicin is a cytotoxic antibiotic which is being used for a wide range of tumors but its prolonged use has lead to cardiomyopathy in numerous cases. Present study was designed to investigate the role of nicardipine- L-type calcium channel blocker, used for the management of hypertension and angina pectoris against the hydroxydaunorubicin induced cardiotoxicity. Sixty Wale-Sprague male rats were used in this study, ranging from 300gm-350gm in weight .The animals were randomly divided into three groups, twenty rats in each group. Group I: (control): received physiological saline (4ml/kg/day), orally for ten consecutive days. Group II (Hydroxydaunorubicin group): received a single dose hydroxydaunorubicin (20mg/kg) intraperitoneally. Group III (pretreatment group): received nicardipine (0.1mg/kg) intraperitoneally daily, starting six days before hydroxydaunorubicin (20mg/kg) and continued for four consecutive days. At the end of the experiment, blood samples were collected for cardiac biomarker determination. The animals were dissected and hearts were taken for histopathological examination. Hydroxydaunorubicin has shown to increase cardiac Troponin I, LDH, MDA, and interleukin-17 significantly (p<0.05) compared to the control group while as pretreatment with nicardipine showed a significant reduction in cardiac biomarkers significantly p<0.05." @default.
- W2341335814 created "2016-06-24" @default.
- W2341335814 creator A5090665178 @default.
- W2341335814 date "2015-11-01" @default.
- W2341335814 modified "2023-09-26" @default.
- W2341335814 title "Advances and Prospects of Nicardipine Effects in Attenuation of Hydroxy-Daunorubicin Induced Acute Cardiotoxicity in rats." @default.
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- W2341335814 doi "https://doi.org/10.19046/abp.v02i06.05" @default.
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