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- W2341376663 abstract "Hepatocellular carcinoma (HCC) is a well-known complication of cirrhosis independent of the etiology of liver disease, and periodic screening is an established practice to detect early HCC in this population. Early detection is critical as there are numerous treatment options for early localized HCC. The known phenomenon of HCC in the absence of cirrhosis in nonalcoholic fatty liver disease (NAFLD) presents a unique problem, as it is not feasible to image all NAFLD patients serially given the 30–40% prevalence of NAFLD in Western populations. Noncirrhotic HCC, arising on a background of NAFLD, has been reported throughout the world and appears to be on the rise. Clinical presentation is varied, and multiple risk factors associated with NAFLD that may also predispose toward HCC have been investigated including obesity, insulin resistance (IR), and iron overload. More recent research efforts have focused on HCC-associated genes and metabolites in NAFLD. This discussion addresses the epidemiology as well as some potential mechanisms behind the occurrence of HCC in noncirrhotic NAFLD." @default.
- W2341376663 created "2016-06-24" @default.
- W2341376663 creator A5065339607 @default.
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- W2341376663 date "2016-02-19" @default.
- W2341376663 modified "2023-10-13" @default.
- W2341376663 title "Occurrence of noncirrhotic HCC in NAFLD" @default.
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- W2341376663 doi "https://doi.org/10.1002/9781118924938.ch7" @default.
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