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- W2341406790 abstract "The prevalence of diabetes and its complications is increasing at an alarming rate in both developed and deve1oping nations. The emerging evidences highlighted that both genetic and epigenetic mechanisms including histone modifications play a significant role in the pathogenesis of diabetic nephropathy (DN). Histone deacetylases (HDACs) and acetylation are involved in the regulation of autophagy as well as pathogenesis of DN. Both HDACs and histone acetyltransferases (HATs) play a key role in chromatin remodeling and affect the transcription of various genes involved in the cellular homeostasis, apoptosis, immunity and angiogenesis. Further, HDAC inhibitors are exert the renoprotective effects in DN and other diabetic complications. Thus, the cellular acetylation plays a crucial role in the regulation of autophagy and can be explored as a new therapeutic target for the treatment of DN. This review aimed to delineate the role of HDACs and associated molecular signaling/pathways in the regulation of autophagy with an emphasis on promising targets for the treatment of DN." @default.
- W2341406790 created "2016-06-24" @default.
- W2341406790 creator A5016068761 @default.
- W2341406790 creator A5016243390 @default.
- W2341406790 creator A5051550137 @default.
- W2341406790 date "2016-09-01" @default.
- W2341406790 modified "2023-10-18" @default.
- W2341406790 title "Role of autophagy and histone deacetylases in diabetic nephropathy: Current status and future perspectives" @default.
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- W2341406790 doi "https://doi.org/10.1016/j.gendis.2016.04.003" @default.
- W2341406790 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6150107" @default.