FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2341444071> ?p ?o ?g. }

• W2341444071 abstract "Materials and Methods: With the approval of the institutional animal care committee, four skeletally mature canines underwent unilateral surgical transection of the cranial cruciate ligament. Animals were euthanized 12 weeks after surgery, the distal femora were removed intact and placed into a special environmental chamber. Matched sites of the weight-bearing surfaces of the medial femoral condyle from unoperated (Ctl) and operated (OA) joints were then indented in four steps (approx. 5, 10, 15, and 20% strain) with a 3 mm diameter round, flat-ended indenter driven by a materials testing machine (MTS). Each step load was applied rapidly then allowed to reach equilibrium over 20 min with continuous recordings of load and displacement. After these tests, the cylindrical osteochondral sample that was located directly beneath the indenter was carefully removed from the joint, cut in half, and stained with the fluorescent nuclear dye Syto-13. The hemi-cylinder was then mounted face-down on a coverglass and visualized by confocal microscopy while a special instrument was used to successively compress the hemi-cylinder (after Guilak (4)). Low-magnification micrographs were used to measure successive changes in overall cartilage thickness and displacements of chondrocyte nuclei in the surface, middle, and deep zones. Results: OA femoral cartilage was approximately half as stiff as site-matched cartilage on the contralateral control femoral condyle (Figure 1). At about 5% overall cartilage strain, the surface zone accounted for the majority of strain in CTL (65%), but reached nearly 90% in OA cartilage; the middle zone accounted for about 25% strain in CTL, but was only about 10% in OA cartilage; the deep zone accounted for about 5% strain in both CTL and OA cartilage. At 10% and 15% overall tissue strains, the surface zone strain in CTL continued to account for about 65% of the total strain; in contrast, surface zone strain in OA cartilage diminished to control values (about 65%) while mid zone strains increased to control levels (about 25%) (Figure 2). Discussion: Although striking changes in the zonal architecture of articular cartilage occur in OA, the functional significance of these changes has remained unclear. The present study suggests that the early functional changes in OA cartilage occur primarily within the surface zone, where the proportion of total tissue strain is abnormally elevated (approximately 35%) during initial loading. These data further suggest that, if tissue strains are transmitted to the chondrocytes in OA cartilage, the likely consequence will be to dramatically alter chondrocyte metabolism and survival in the surface zone and to damage the extracellular matrix, possibly initiating or exacerbating cartilage fibrillation." @default.
• W2341444071 created "2016-06-24" @default.
• W2341444071 creator A5077397108 @default.
• W2341444071 date "2001-01-01" @default.
• W2341444071 modified "2023-09-26" @default.
• W2341444071 title "ZONAL DISTRIBUTION OF ARTICULAR CARTILAGE COMPRESSIVE STRAIN IN A MODEL OF EARLY EXPERIMENTAL OSTEOARTHRITIS" @default.
• W2341444071 hasPublicationYear "2001" @default.
• W2341444071 type Work @default.
• W2341444071 sameAs 2341444071 @default.
• W2341444071 citedByCount "0" @default.
• W2341444071 crossrefType "journal-article" @default.
• W2341444071 hasAuthorship W2341444071A5077397108 @default.
• W2341444071 hasConcept C105702510 @default.
• W2341444071 hasConcept C136229726 @default.
• W2341444071 hasConcept C142724271 @default.
• W2341444071 hasConcept C192562407 @default.
• W2341444071 hasConcept C204787440 @default.
• W2341444071 hasConcept C2776164576 @default.
• W2341444071 hasConcept C2776626428 @default.
• W2341444071 hasConcept C2778022156 @default.
• W2341444071 hasConcept C2778434673 @default.
• W2341444071 hasConcept C2779699715 @default.
• W2341444071 hasConcept C2780550940 @default.
• W2341444071 hasConcept C2910895738 @default.
• W2341444071 hasConcept C71924100 @default.
• W2341444071 hasConcept C96646087 @default.
• W2341444071 hasConceptScore W2341444071C105702510 @default.
• W2341444071 hasConceptScore W2341444071C136229726 @default.
• W2341444071 hasConceptScore W2341444071C142724271 @default.
• W2341444071 hasConceptScore W2341444071C192562407 @default.
• W2341444071 hasConceptScore W2341444071C204787440 @default.
• W2341444071 hasConceptScore W2341444071C2776164576 @default.
• W2341444071 hasConceptScore W2341444071C2776626428 @default.
• W2341444071 hasConceptScore W2341444071C2778022156 @default.
• W2341444071 hasConceptScore W2341444071C2778434673 @default.
• W2341444071 hasConceptScore W2341444071C2779699715 @default.
• W2341444071 hasConceptScore W2341444071C2780550940 @default.
• W2341444071 hasConceptScore W2341444071C2910895738 @default.
• W2341444071 hasConceptScore W2341444071C71924100 @default.
• W2341444071 hasConceptScore W2341444071C96646087 @default.
• W2341444071 hasLocation W23414440711 @default.
• W2341444071 hasOpenAccess W2341444071 @default.
• W2341444071 hasPrimaryLocation W23414440711 @default.
• W2341444071 hasRelatedWork W1661953964 @default.
• W2341444071 hasRelatedWork W1824951580 @default.
• W2341444071 hasRelatedWork W1935888897 @default.
• W2341444071 hasRelatedWork W1958662139 @default.
• W2341444071 hasRelatedWork W1973717169 @default.
• W2341444071 hasRelatedWork W1983262993 @default.
• W2341444071 hasRelatedWork W2006408381 @default.
• W2341444071 hasRelatedWork W2043789940 @default.
• W2341444071 hasRelatedWork W2070871662 @default.
• W2341444071 hasRelatedWork W2113946198 @default.
• W2341444071 hasRelatedWork W2131347621 @default.
• W2341444071 hasRelatedWork W2144001850 @default.
• W2341444071 hasRelatedWork W2264621688 @default.
• W2341444071 hasRelatedWork W2377124713 @default.
• W2341444071 hasRelatedWork W2405786605 @default.
• W2341444071 hasRelatedWork W2550325069 @default.
• W2341444071 hasRelatedWork W2795241616 @default.
• W2341444071 hasRelatedWork W2973209192 @default.
• W2341444071 hasRelatedWork W3029453976 @default.
• W2341444071 hasRelatedWork W3128638632 @default.
• W2341444071 isParatext "false" @default.
• W2341444071 isRetracted "false" @default.
• W2341444071 magId "2341444071" @default.
• W2341444071 workType "article" @default.