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• W2341453670 abstract "Objective: To evaluate the protective efficacy of certain chemoprotectants against cyclic peptide hepatotoxic microcystin-LR in mice. Material and Methods: Swiss albino female mice were used in all experiments for screening antidotes against the lethal dose of microcystin-LR (100 µg/kg body weight, i.p.). The agents, Dglucose, mannitol, dihydroxyacetone, Trolox ® , L-cysteine, N-acetylcysteine, amifostine, glutathione, silymarin, naringin, rifampin and cyclosporin-a were administered as either pre-treatment (1, 3 and 24 h), co-administration or post-treatment. Percent survival and time to death were monitored. The biochemical profile of protected animals was monitored 24 h post-treatment. Results: D-glucose, mannitol, L-cysteine, naringin and amifostine extended the survival time of animals but offered no protection against lethality. N-acetylcysteine, glutathione and Trolox ® gave partial protection (25-50%) on pretreatment or co-administration. Complete protection was observed with rifampin (25 mg/kg), cyclosporin-A (10 mg/kg) and silymarin (400 mg/kg) when given as pre-treatment. In addition, rifampin and cyclosprin-A gave complete protection when co-administered with microcystin-LR. Rifampin was the only agent which gave protection at 15 min post-treatment. The biochemical profile of surviving animals 24 h after treatment showed increased liver body weight index and levels of hepatic enzymes viz. LDH, ALT, SDH in serum. Conclusion: Chemoprotectants that can inhibit the specific uptake of toxin into the liver can be promising antidotes against lethal poisoning by microcystin-LR in mice." @default.
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• W2341453670 date "2004-01-01" @default.
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• W2341453670 title "Screening of certain chemoprotectants against Screening of certain chemoprotectants against Screening of certain chemoprotectants against Screening of certain chemoprotectants against Screening of certain chemoprotectants against cyclic peptide toxin microcystin cyclic peptide toxin microcystin cyclic peptide toxin microcystin cyclic peptide toxin microcystin cyclic peptide toxin microcystin-LR -LR -LR -LR -LR" @default.
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