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- W2341492022 abstract "Platelets unexpectedly contain a subset of intronic-rich pre-mRNAs that are processed into translatable message in response to activating signals. Here we report that signaling through Clk1 and SF2/ASF, activated Clk1 induces SF2/ASF phosphorylation, regulates mRNA processing in platelets and identify tissue factor (TF) as a pre-mRNA that is under signal-dependent control. Megakaryocytes deliver Clk1 to proplatelets, and mature platelets mobilize Clk1 to focal adhesion complexes as they adhere and spread on fibrinogen. Activated platelets splice TF pre-mRNA into translatable message and generate TF protein and activity (10-fold increase, quiescent vs. activated platelets) on their surface through Clk1-dependent mechanisms. Interruption of Clk1 signaling with a benzothiazole compound blocks this process (75% reduced TF activity). Together, these studies demonstrate that Clk1 and SF2/ASF regulate pre-mRNA processing in platelets and identify a previously unrecognized role for signal-dependent pre-mRNA splicing in controlling the surface thrombogenecity of activated platelets." @default.
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- W2341492022 date "2006-03-01" @default.
- W2341492022 modified "2023-09-26" @default.
- W2341492022 title "Signal dependent pre‐mRNA splicing regulates the surface thrombogenecity of platelets" @default.
- W2341492022 doi "https://doi.org/10.1096/fasebj.20.4.a666-b" @default.
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