Matches in SemOpenAlex for { <https://semopenalex.org/work/W2341501812> ?p ?o ?g. }
- W2341501812 abstract "Prostate cancer (PC) is the most common neoplasia among males from developed countries and the second leading cause of death from cancer in these males. During the last years, serum prostate specific antigen (PSA) has been used as biomarker for PC diagnosis. Although PSA test has increased PC detection, it has a low specificity and leads to over-diagnosis and over-treatment; therefore, it is necessary to improve the current diagnostic methods for PC. In the past decade, urine has received more and more attention for its simplicity, as well as its potential use in identifying new biomarkers as non-invasive detection method. Deregulation of microRNAs (miRNAs) in serum/plasma or tissue has been associated with many diseases including PC, suggesting the possible use of miRNAs as diagnostic biomarkers also in other body fluids. The intent of my PhD research program was to evaluate if miRNAs known to be deregulated in blood or tissue for PC could also be detected in urine from cellular fraction, and characterize the function of the most promising of them. By analysing a large cohort of post-digital rectal exam (DRE) urine samples, we have validated a miRNA panel consisting of 3 urinary miRNAs (miR-648, miR-147b and miR-193a-5p) with a predictive value of area under the curve (AUC): 0,74 In addition, we have determined that miRNAs-miR-28 and miR-210 are under-expressed in PC urine and associated with PC development and progression, mainly affecting PC cell proliferation and migration. Overall, this work introduces novel candidate miRNAs that are aberrantly expressed in PC as diagnostic biomarkers, and perhaps aids in defining how miRNAs might one day serve as anti-cancer therapeutic agents" @default.
- W2341501812 created "2016-06-24" @default.
- W2341501812 creator A5028958766 @default.
- W2341501812 date "2015-11-26" @default.
- W2341501812 modified "2023-09-22" @default.
- W2341501812 title "Micrornas as predictors and therapy for prostate cancer" @default.
- W2341501812 cites W144423133 @default.
- W2341501812 cites W1490597121 @default.
- W2341501812 cites W1525649758 @default.
- W2341501812 cites W1540670422 @default.
- W2341501812 cites W1541370161 @default.
- W2341501812 cites W1549382495 @default.
- W2341501812 cites W1568934836 @default.
- W2341501812 cites W1601396276 @default.
- W2341501812 cites W1634080553 @default.
- W2341501812 cites W1744887380 @default.
- W2341501812 cites W1839893894 @default.
- W2341501812 cites W1926129581 @default.
- W2341501812 cites W1963691340 @default.
- W2341501812 cites W1963747040 @default.
- W2341501812 cites W1963966397 @default.
- W2341501812 cites W1964453634 @default.
- W2341501812 cites W1965815433 @default.
- W2341501812 cites W1966101011 @default.
- W2341501812 cites W1967290941 @default.
- W2341501812 cites W1967484155 @default.
- W2341501812 cites W1967765631 @default.
- W2341501812 cites W1968968087 @default.
- W2341501812 cites W1969270395 @default.
- W2341501812 cites W1970633843 @default.
- W2341501812 cites W1973435573 @default.
- W2341501812 cites W1975775399 @default.
- W2341501812 cites W1976355133 @default.
- W2341501812 cites W1976883684 @default.
- W2341501812 cites W1978560967 @default.
- W2341501812 cites W1979413046 @default.
- W2341501812 cites W1980227290 @default.
- W2341501812 cites W1983937756 @default.
- W2341501812 cites W1984608866 @default.
- W2341501812 cites W1985098845 @default.
- W2341501812 cites W1985123329 @default.
- W2341501812 cites W1985213644 @default.
- W2341501812 cites W1985898827 @default.
- W2341501812 cites W1990308608 @default.
- W2341501812 cites W1991034124 @default.
- W2341501812 cites W1993002585 @default.
- W2341501812 cites W1994606654 @default.
- W2341501812 cites W1995195592 @default.
- W2341501812 cites W1997367235 @default.
- W2341501812 cites W1998449659 @default.
- W2341501812 cites W1998466267 @default.
- W2341501812 cites W1999797207 @default.
- W2341501812 cites W2004756708 @default.
- W2341501812 cites W2005303835 @default.
- W2341501812 cites W2006115709 @default.
- W2341501812 cites W2006206761 @default.
- W2341501812 cites W2007824082 @default.
- W2341501812 cites W2010393075 @default.
- W2341501812 cites W2011925011 @default.
- W2341501812 cites W2013824417 @default.
- W2341501812 cites W2014164699 @default.
- W2341501812 cites W2016404946 @default.
- W2341501812 cites W2020170641 @default.
- W2341501812 cites W2021992979 @default.
- W2341501812 cites W2025449301 @default.
- W2341501812 cites W2027097496 @default.
- W2341501812 cites W2027142966 @default.
- W2341501812 cites W2028652213 @default.
- W2341501812 cites W2030331235 @default.
- W2341501812 cites W2030701238 @default.
- W2341501812 cites W2030712838 @default.
- W2341501812 cites W2033479946 @default.
- W2341501812 cites W2033681249 @default.
- W2341501812 cites W2034829050 @default.
- W2341501812 cites W2034876822 @default.
- W2341501812 cites W2037089056 @default.
- W2341501812 cites W2039869205 @default.
- W2341501812 cites W2040182688 @default.
- W2341501812 cites W2040196938 @default.
- W2341501812 cites W2041983200 @default.
- W2341501812 cites W2042407522 @default.
- W2341501812 cites W2043960161 @default.
- W2341501812 cites W2044512288 @default.
- W2341501812 cites W2046314136 @default.
- W2341501812 cites W2046409229 @default.
- W2341501812 cites W2048548999 @default.
- W2341501812 cites W2048603557 @default.
- W2341501812 cites W2050822362 @default.
- W2341501812 cites W2051710823 @default.
- W2341501812 cites W2053960955 @default.
- W2341501812 cites W2056680747 @default.
- W2341501812 cites W2058729746 @default.
- W2341501812 cites W2059357290 @default.
- W2341501812 cites W2061869578 @default.
- W2341501812 cites W2062355315 @default.
- W2341501812 cites W2062398289 @default.
- W2341501812 cites W2064184151 @default.
- W2341501812 cites W2066151767 @default.
- W2341501812 cites W2066300395 @default.
- W2341501812 cites W2071593083 @default.