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- W2341502679 abstract "Asthma in children and young adults is strongly associated with immediate hyersensitivity to indoor aller gens, notably those derived from the house dust mite. In addition, outdoor air pollution is considered to aggravate existing asthma. We investigated the prevalence of asthma and the pattern of allergen sensitiza tion in a mite-free environment with low levels of outdoor air pollution. A total of 567 children aged between 12 and 14attending Los Alamos Middle School, NM (altitude 7,200 feet) were screened using a respiratory questionnaire; 120 children (53 control children) underwent allergen skin testing and serum IgE measure ment, and their bronchial reactivity to histamine was measured. Dust was collected from 111 homes and the level of indoor mite and cat allergen measured. The prevalence of respiratory symptoms was high (13%), and from the detailed testing it was estimated that,6.3% of the children had asthma (defined as symptom atic bronchial reactivity). Children with asthma had elevated IgE, 367 (179to 755) versus 38 (23 to 61), and predominant sensitization to cat, 68 versus 20% (p < 0.001). A high number of households (77%) had a pet cat or dog. The concentration of mite allergen was very low (mean 0.181lgDer p I/g sieved house dust), whereas that of cat allergen was high in homes with a cat (80.8 Ilg Fel d I/g) but also in homes with no cat (3.2 Ilg Feld I/g). The results show that in a mite-free environment with low levels of outdoor air pollution, asthma was still a major cause of morbidity among schoolchildren. Asthma was strongly associated with elevated IgE and sensitization to other indoor allergens, notably those derived from cat. Sporik R, Ingram JM, Price W, Sussman JH, Honsinger RW, Platts-Mills TAE. Association of asthma with serum IgE and skin test reactivity to allergens among children liVing at high altitude: tickling the dragon's breath. Am J Respir Crit Care Med 1995;151:1388-92." @default.
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- W2341502679 date "1995-01-01" @default.
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- W2341502679 title "to Allergens Among Children Living at High Altitude Tickling the Dragon's Breath" @default.
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