Matches in SemOpenAlex for { <https://semopenalex.org/work/W2341506033> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2341506033 endingPage "8" @default.
- W2341506033 startingPage "1943" @default.
- W2341506033 abstract "To report clinical outcomes of a consecutive series of patients with early-stage (T1-T1N0) anal cancer treated with intensity-modulated radiotherapy (IMRT) and a simultaneous integrated boost (SIB) approach similarly to the RTOG 05-29 trial.A cohort of 43 patients underwent SIB-IMRT employing a schedule consisting of 50.4 Gy/28 fractions to the gross tumor volume and 42 Gy/28 fractions to the elective nodal volumes for cT1N0 cases, and 54 Gy/30 fractions and 45 Gy/30 fractions to the same volumes for cT2N0 cases. Chemotherapy was administered concurrently following Nigro's regimen. The primary endpoint was colostomy-free survival (CFS). Secondary endpoints were locoregional control (LRC), disease-free (DFS), cancer-specific (CSS) and overall (OS) survival.Median follow-up was 39.7 months. The actuarial 3-year CFS was 79.4% [95% confidence interval (CI)=61.4-89.7%]. Actuarial 3-year OS and CSS were 90.8% (95% CI=74.1-96.9%) and 93.8% (95% CI=77.3-98.4%), while DFS was 75.5% (95% CI=56.4-87.1%). Actuarial 3-year LRC was 86.1% (95% CI=69.6-94%). On multivariate analysis, tumor size >3 cm showed a trend towards significance in predicting CFS [hazard ratio (HR)=8.6, 95% CI=84.7-88.1%; p=0.069]. Maximum detected adverse events included: skin (G3): 18%; gastrointestinal tract (G2): 67%; genitourinary tract (G3): 3%; genitalia (G2): 30%; anemia (G2): 7%; leukopenia (G3): 26%, leukopenia (G4):7%; neutropenia (G3): 15%; neutropenia (G4): 12%; thrombocytopenia (G3): 9%.Our clinical results support the use of SIB-IMRT in the combined modality treatment of patients with anal cancer." @default.
- W2341506033 created "2016-06-24" @default.
- W2341506033 creator A5014215750 @default.
- W2341506033 creator A5019407140 @default.
- W2341506033 creator A5039214771 @default.
- W2341506033 creator A5045011793 @default.
- W2341506033 creator A5060509370 @default.
- W2341506033 creator A5061193350 @default.
- W2341506033 creator A5063189503 @default.
- W2341506033 creator A5064610252 @default.
- W2341506033 creator A5072280418 @default.
- W2341506033 date "2016-04-01" @default.
- W2341506033 modified "2023-09-23" @default.
- W2341506033 title "Early-stage Node-negative (T1-T2N0) Anal Cancer Treated with Simultaneous Integrated Boost Radiotherapy and Concurrent Chemotherapy." @default.
- W2341506033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27069184" @default.
- W2341506033 hasPublicationYear "2016" @default.
- W2341506033 type Work @default.
- W2341506033 sameAs 2341506033 @default.
- W2341506033 citedByCount "11" @default.
- W2341506033 countsByYear W23415060332016 @default.
- W2341506033 countsByYear W23415060332017 @default.
- W2341506033 countsByYear W23415060332018 @default.
- W2341506033 countsByYear W23415060332019 @default.
- W2341506033 countsByYear W23415060332020 @default.
- W2341506033 crossrefType "journal-article" @default.
- W2341506033 hasAuthorship W2341506033A5014215750 @default.
- W2341506033 hasAuthorship W2341506033A5019407140 @default.
- W2341506033 hasAuthorship W2341506033A5039214771 @default.
- W2341506033 hasAuthorship W2341506033A5045011793 @default.
- W2341506033 hasAuthorship W2341506033A5060509370 @default.
- W2341506033 hasAuthorship W2341506033A5061193350 @default.
- W2341506033 hasAuthorship W2341506033A5063189503 @default.
- W2341506033 hasAuthorship W2341506033A5064610252 @default.
- W2341506033 hasAuthorship W2341506033A5072280418 @default.
- W2341506033 hasConcept C121608353 @default.
- W2341506033 hasConcept C126322002 @default.
- W2341506033 hasConcept C126894567 @default.
- W2341506033 hasConcept C141071460 @default.
- W2341506033 hasConcept C203092338 @default.
- W2341506033 hasConcept C207103383 @default.
- W2341506033 hasConcept C2776694085 @default.
- W2341506033 hasConcept C2777063308 @default.
- W2341506033 hasConcept C2780873365 @default.
- W2341506033 hasConcept C2781413609 @default.
- W2341506033 hasConcept C44249647 @default.
- W2341506033 hasConcept C509974204 @default.
- W2341506033 hasConcept C530470458 @default.
- W2341506033 hasConcept C535046627 @default.
- W2341506033 hasConcept C71924100 @default.
- W2341506033 hasConcept C90924648 @default.
- W2341506033 hasConceptScore W2341506033C121608353 @default.
- W2341506033 hasConceptScore W2341506033C126322002 @default.
- W2341506033 hasConceptScore W2341506033C126894567 @default.
- W2341506033 hasConceptScore W2341506033C141071460 @default.
- W2341506033 hasConceptScore W2341506033C203092338 @default.
- W2341506033 hasConceptScore W2341506033C207103383 @default.
- W2341506033 hasConceptScore W2341506033C2776694085 @default.
- W2341506033 hasConceptScore W2341506033C2777063308 @default.
- W2341506033 hasConceptScore W2341506033C2780873365 @default.
- W2341506033 hasConceptScore W2341506033C2781413609 @default.
- W2341506033 hasConceptScore W2341506033C44249647 @default.
- W2341506033 hasConceptScore W2341506033C509974204 @default.
- W2341506033 hasConceptScore W2341506033C530470458 @default.
- W2341506033 hasConceptScore W2341506033C535046627 @default.
- W2341506033 hasConceptScore W2341506033C71924100 @default.
- W2341506033 hasConceptScore W2341506033C90924648 @default.
- W2341506033 hasIssue "4" @default.
- W2341506033 hasLocation W23415060331 @default.
- W2341506033 hasOpenAccess W2341506033 @default.
- W2341506033 hasPrimaryLocation W23415060331 @default.
- W2341506033 hasRelatedWork W1836187181 @default.
- W2341506033 hasRelatedWork W1999563708 @default.
- W2341506033 hasRelatedWork W2033602715 @default.
- W2341506033 hasRelatedWork W2091151588 @default.
- W2341506033 hasRelatedWork W2104255120 @default.
- W2341506033 hasRelatedWork W2359878197 @default.
- W2341506033 hasRelatedWork W2391405092 @default.
- W2341506033 hasRelatedWork W2787943852 @default.
- W2341506033 hasRelatedWork W4226112493 @default.
- W2341506033 hasRelatedWork W1845720505 @default.
- W2341506033 hasVolume "36" @default.
- W2341506033 isParatext "false" @default.
- W2341506033 isRetracted "false" @default.
- W2341506033 magId "2341506033" @default.
- W2341506033 workType "article" @default.