FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2341520504> ?p ?o ?g. }

• W2341520504 abstract "ABSTRACT Antibiotic resistance is a worldwide health risk, but the influence of animal agriculture on the genetic context and enrichment of individual antibiotic resistance alleles remains unclear. Using quantitative PCR followed by amplicon sequencing, we quantified and sequenced 44 genes related to antibiotic resistance, mobile genetic elements, and bacterial phylogeny in microbiomes from U.S. laboratory swine and from swine farms from three Chinese regions. We identified highly abundant resistance clusters: groups of resistance and mobile genetic element alleles that cooccur. For example, the abundance of genes conferring resistance to six classes of antibiotics together with class 1 integrase and the abundance of IS 6100 -type transposons in three Chinese regions are directly correlated. These resistance cluster genes likely colocalize in microbial genomes in the farms. Resistance cluster alleles were dramatically enriched (up to 1 to 10% as abundant as 16S rRNA) and indicate that multidrug-resistant bacteria are likely the norm rather than an exception in these communities. This enrichment largely occurred independently of phylogenetic composition; thus, resistance clusters are likely present in many bacterial taxa. Furthermore, resistance clusters contain resistance genes that confer resistance to antibiotics independently of their particular use on the farms. Selection for these clusters is likely due to the use of only a subset of the broad range of chemicals to which the clusters confer resistance. The scale of animal agriculture and its wastes, the enrichment and horizontal gene transfer potential of the clusters, and the vicinity of large human populations suggest that managing this resistance reservoir is important for minimizing human risk. IMPORTANCE Agricultural antibiotic use results in clusters of cooccurring resistance genes that together confer resistance to multiple antibiotics. The use of a single antibiotic could select for an entire suite of resistance genes if they are genetically linked. No links to bacterial membership were observed for these clusters of resistance genes. These findings urge deeper understanding of colocalization of resistance genes and mobile genetic elements in resistance islands and their distribution throughout antibiotic-exposed microbiomes. As governments seek to combat the rise in antibiotic resistance, a balance is sought between ensuring proper animal health and welfare and preserving medically important antibiotics for therapeutic use. Metagenomic and genomic monitoring will be critical to determine if resistance genes can be reduced in animal microbiomes, or if these gene clusters will continue to be coselected by antibiotics not deemed medically important for human health but used for growth promotion or by medically important antibiotics used therapeutically." @default.
• W2341520504 created "2016-06-24" @default.
• W2341520504 creator A5003288277 @default.
• W2341520504 creator A5035323521 @default.
• W2341520504 creator A5036886676 @default.
• W2341520504 creator A5041807449 @default.
• W2341520504 creator A5060449666 @default.
• W2341520504 creator A5062493663 @default.
• W2341520504 creator A5071894027 @default.
• W2341520504 creator A5083279403 @default.
• W2341520504 date "2016-05-04" @default.
• W2341520504 modified "2023-10-18" @default.
• W2341520504 title "Clusters of Antibiotic Resistance Genes Enriched Together Stay Together in Swine Agriculture" @default.
• W2341520504 cites W1481643432 @default.
• W2341520504 cites W1906741485 @default.
• W2341520504 cites W1965260838 @default.
• W2341520504 cites W1967962707 @default.
• W2341520504 cites W1985716049 @default.
• W2341520504 cites W1985886752 @default.
• W2341520504 cites W1990829520 @default.
• W2341520504 cites W1992607648 @default.
• W2341520504 cites W1993048301 @default.
• W2341520504 cites W1995274825 @default.
• W2341520504 cites W1995441479 @default.
• W2341520504 cites W1998157707 @default.
• W2341520504 cites W2004960255 @default.
• W2341520504 cites W2006805047 @default.
• W2341520504 cites W2008243541 @default.
• W2341520504 cites W2012365024 @default.
• W2341520504 cites W2021419056 @default.
• W2341520504 cites W2022051546 @default.
• W2341520504 cites W2028449912 @default.
• W2341520504 cites W2028574557 @default.
• W2341520504 cites W2033024573 @default.
• W2341520504 cites W2035906300 @default.
• W2341520504 cites W2037900484 @default.
• W2341520504 cites W2038752330 @default.
• W2341520504 cites W2045817362 @default.
• W2341520504 cites W2048755204 @default.
• W2341520504 cites W2050116248 @default.
• W2341520504 cites W2053523556 @default.
• W2341520504 cites W2057710367 @default.
• W2341520504 cites W2058952776 @default.
• W2341520504 cites W2060948639 @default.
• W2341520504 cites W2061547064 @default.
• W2341520504 cites W2066916220 @default.
• W2341520504 cites W2070755960 @default.
• W2341520504 cites W2079752712 @default.
• W2341520504 cites W2083963531 @default.
• W2341520504 cites W2092643722 @default.
• W2341520504 cites W2093942641 @default.
• W2341520504 cites W2099772108 @default.
• W2341520504 cites W2101571099 @default.
• W2341520504 cites W2103784576 @default.
• W2341520504 cites W2104750596 @default.
• W2341520504 cites W2107572188 @default.
• W2341520504 cites W2108638835 @default.
• W2341520504 cites W2108817592 @default.
• W2341520504 cites W2110459646 @default.
• W2341520504 cites W2113828015 @default.
• W2341520504 cites W2115486016 @default.
• W2341520504 cites W2117457769 @default.
• W2341520504 cites W2118701853 @default.
• W2341520504 cites W2120316710 @default.
• W2341520504 cites W2130535927 @default.
• W2341520504 cites W2134830426 @default.
• W2341520504 cites W2136879569 @default.
• W2341520504 cites W2138952930 @default.
• W2341520504 cites W2140212438 @default.
• W2341520504 cites W2143445148 @default.
• W2341520504 cites W2144203006 @default.
• W2341520504 cites W2151350595 @default.
• W2341520504 cites W2160302809 @default.
• W2341520504 cites W2166801599 @default.
• W2341520504 cites W2169042993 @default.
• W2341520504 cites W2169163713 @default.
• W2341520504 cites W2180695509 @default.
• W2341520504 cites W2289035228 @default.
• W2341520504 cites W2325966728 @default.
• W2341520504 cites W2333287207 @default.
• W2341520504 cites W4211090384 @default.
• W2341520504 doi "https://doi.org/10.1128/mbio.02214-15" @default.
• W2341520504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4959523" @default.
• W2341520504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27073098" @default.
• W2341520504 hasPublicationYear "2016" @default.
• W2341520504 type Work @default.
• W2341520504 sameAs 2341520504 @default.
• W2341520504 citedByCount "153" @default.
• W2341520504 countsByYear W23415205042016 @default.
• W2341520504 countsByYear W23415205042017 @default.
• W2341520504 countsByYear W23415205042018 @default.
• W2341520504 countsByYear W23415205042019 @default.
• W2341520504 countsByYear W23415205042020 @default.
• W2341520504 countsByYear W23415205042021 @default.
• W2341520504 countsByYear W23415205042022 @default.
• W2341520504 countsByYear W23415205042023 @default.
• W2341520504 crossrefType "journal-article" @default.
• W2341520504 hasAuthorship W2341520504A5003288277 @default.
• W2341520504 hasAuthorship W2341520504A5035323521 @default.
• W2341520504 hasAuthorship W2341520504A5036886676 @default.

• next