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- W2341551983 abstract "271 Objectives Carcinoid lung tumors are an uncommon group (1%-6%) of all lung tumors, developing from neuroendocrine cells. The latest development in the imaging of NETs is the fusion of anatomical and functional modalities - PET-CT and SPECT-CT. The aim of this work was to evaluate clinical application of 99mTc-Tektrotyd SPECT-CT studies for diagnosis, staging and follow-up of patients with NETs. Methods Twenty-one pts: 19 with pulmonary and 2 with mediastinal tumors with neuroendocrine differentiation (50%-100% positive-staining tumor cells) were studied: 8 were with Large cell NE carcinomas, 7 were with SCLC, 2 were with mediastinal NETs 4 were with metastatic lesions from tumor with unknown primary origin (UPO), expressed NE markers, suspective for lung NE origin . 48 examinations including SPECT-CT studies of the chest and/or abdomen were performed 2-4 hrs post i.v.inj. of 740 MBq 99mTc-HYNIC-TOC (Tektrotyd, Polatom). This tracer has high affinity to SSTR2 and lower to SSTR3 and SSTR5. SPECT-CT gamma camera Symbia T2, Siemens with Low Dose CT was used. Our results were interpreted based on all other clinical and radiological data. Results In 4 pts with UPO, primary lung NE tumors were visualised, proven histologically. For exact N- and M-staging somatostatin SPECT-CT scintigraphy was performed in 17 pts: loco-regional mediastinal and hilar lymphadenopathy, distant liver, pulmonary, bone and suprarenal positive metastatic lesions were imaged in 15 pts, showing a good correlation with increased level of secret serum marker - CgA. There was not a tracer uptake in 3 pts with liver multiple secondary lesions due to metastatic dedifferentiation. Conclusions SPECT-CT with 99mTc-Tektrotyd is used to select essential information for imaging of primary lung NE tumor in cases with metastatic lesions from tumor with UPO; N/M staging; assessing SSTR status and making decision on the most appropriate therapy regimens" @default.
- W2341551983 created "2016-06-24" @default.
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- W2341551983 date "2015-05-01" @default.
- W2341551983 modified "2023-09-25" @default.
- W2341551983 title "Role of 99mTc-Tektrotyd SPECT-CT in patients with pulmonary neuroendocrine tumors (NETs)" @default.
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