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• W2341567225 endingPage "118" @default.
• W2341567225 startingPage "107" @default.
• W2341567225 abstract "Typically disease-causing CAG/CTG repeats expand, but rare affected families can display high levels of contraction of the expanded repeat amongst offspring. Understanding instability is important since arresting expansions or enhancing contractions could be clinically beneficial. The MutSβ mismatch repair complex is required for CAG/CTG expansions in mice and patients. Oddly, by unknown mechanisms MutSβ-deficient mice incur contractions instead of expansions. Replication using CTG or CAG as the lagging strand template is known to cause contractions or expansions respectively; however, the interplay between replication and repair leading to this instability remains unclear. Towards understanding how repeat contractions may arise, we performed in vitro SV40-mediated replication of repeat-containing plasmids in the presence or absence of mismatch repair. Specifically, we separated repair from replication: Replication mediated by MutSβ- and MutSα-deficient human cells or cell extracts produced slipped-DNA heteroduplexes in the contraction- but not expansion-biased replication direction. Replication in the presence of MutSβ disfavoured the retention of replication products harbouring slipped-DNA heteroduplexes. Post-replication repair of slipped-DNAs by MutSβ-proficient extracts eliminated slipped-DNAs. Thus, a MutSβ-deficiency likely enhances repeat contractions because MutSβ protects against contractions by repairing template strand slip-outs. Replication deficient in LigaseI or PCNA-interaction mutant LigaseI revealed slipped-DNA formation at lagging strands. Our results reveal that distinct mechanisms lead to expansions or contractions and support inhibition of MutSβ as a therapeutic strategy to enhance the contraction of expanded repeats." @default.
• W2341567225 created "2016-06-24" @default.
• W2341567225 creator A5003935831 @default.
• W2341567225 creator A5048073761 @default.
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• W2341567225 creator A5051816777 @default.
• W2341567225 creator A5057459440 @default.
• W2341567225 creator A5087128310 @default.
• W2341567225 date "2016-06-01" @default.
• W2341567225 modified "2023-10-16" @default.
• W2341567225 title "Absence of MutSβ leads to the formation of slipped-DNA for CTG/CAG contractions at primate replication forks" @default.
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