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• W2341574359 abstract "BackFlround: Substance P (SP) is increased in the inflamed intestine of Trichinella spiralis-infected rats, but the underlying mechanism is unknown. lnterleukin lb (IL-lb) messenger RNA and protein is expressed in the longitudinal muscle-myenteric plexus (LM-MP) of this model. Thus, the purpose of the study was to examine the ability of human recombinant IL-lb (hrlL-18) to increase SP in LM-MP preparations from the intestine of noninfected rats. Methods: LM-MP preparations were incubated with hrlL-lb, and immunoreactive SP (IR-SP) was assessed in the tissues by radioimmunossay or immunohistochemistry. Results: hrlL-lp increased IR-SP in the tissue in a time- and concentration-dependent manner, being maximal after 6 hours at a concentration of 10 ng/mL. The IR-SP could be depleted by scorpion venom, and immunohistochemistry revealed increased staining for SP within nerves of the LM-MP. The action of IL-lb was dependent on protein synthesis, was receptor mediated, and was not due to endotoxin contamination of the cytokine preparation. Conclusions: hrlL-lfi stimulates the synthesis of SP in myenteric nerves of rat intestine. S ubstance P (SP) is a widely distributed neuropeptide. that increases in concentration in inflamed tissues, where it is believed to contribute to the inflammatory process.’ There are, however, conflicting reports regarding increases in the SP content of the gut in patients with inflammatory bowel disease.2-4 Nevertheless, Mantyh et a1.5 showed an up-regulation of SP receptors on arterioles, venules, and lymphoid tissue in the intestinal mucosa of patients with Crohn’s disease and speculated that this may have bearing not only on the inflammatory process, but also on the processing of sensory information in the inflamed gut.’ We have studied the impact of inflammation on intestinal function using Trikbinela spiralis-infected rats as a model and have shown changes in cholinergic,’ adrenergic,’ and peptidergic” nerves in the inflamed jejunum. We found a fivefold increase in immunoreactive SP (IR-SP) in the longitudinal muscle-myenteric plexus (LM-MP) region of the inflamed jejunum; the increased IR-SP could be depleted by scorpion venom treatment of the tissue in vitro, indicating that the neuropeptide was contained in nerves.” No increases in IR-SP were observed in the noninflamed ileum of this model, and attenuation of the inflammatory response by corticosteroid treatment prevented the increase in IR-SP. These findings led us to conclude that the increased neuronal IR-SP content was a result of the inflammatory process. Subsequent studies from this laboratory have addressed putative inflammatory mediators of the abovedescribed changes in myenteric nerves in the T. spiralis-infected rat. Recently, we have shown an increase in the expression of messenger RNA (mRNA) for several cytokines in the LM-MP region of the inflamed jejunum of T. spiralis-infected rats.” In particular, we documented increased expression of interleukin 1 p (IL- 1 p) mRNA and protein in the LM-MP of this model, and it has been shown that IL-1p induces an increase in SP in sympathetic ganglia.” Thus, the purpose of the present study was to investigate the ability of human recombinant IL-l/3 (hrIL1 p) to increase IR-SP in LM-MP preparations from rat jejunum." @default.
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• W2341574359 date "1993-01-01" @default.
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• W2341574359 title "lnterleukin 1 P-Induced Increase in Substance Myenteric Plexus P in Rat" @default.
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