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• W2341596828 abstract "A. Chovnick, W. Gelbart* and M. McCarron Genetics and Cell Biology Section Biological Sciences Group The University of Connecticut Storrs. Connecticut 06268 One of the critical issues in eucaryotic molecular genetics is the nature of control elements and their relationship to the structural elements that they regulate. A particularly favorable system for investi- gating such questions is provided by the rosy locus of Drosophila melanogaster. Originally recovered and defined as recessive brownish eye color mutants, rosy mutants were shown subsequently to be deficient in red (drosop- terin) pigment and to exhibit no detectable xan- thine dehydrogenase (XDH) activity (Glassman and Mitchell, 1959). Figure 1 summarizes reactions used in this laboratory to assay Drosophila XDH (Forrest, Glassman and Mitchell, 1956; Glassman and Mitchell, 1959). Of particular interest is the fact that zygotes possessing little or no XDH activity are unable to complete development and die before eclosion on standard Drosophila culture medium supplemented with purine (Glassman, 1965). Two observations serve to place the coding information for XDH in or near rosy: first, variation in dosage of ry+ alleles, from O-3 doses, appears to be the limit- ing factor in determining level of XDH activity/fly in otherwise wild-type flies (Grell, 1962; Glassman, Karam and Keller, 1962); second, the genetic basis for variation in electrophoretic mobility of XDH seen in wild-type strains maps to the immediate vicinity of the rosy locus (Yen and Glassman, 1965). All these observations have been confirmed and extended in this laboratory (Chovnick, 1966; Fin- nerty, Baillie and Chovnick, 1970; McCarron, Gel- bart and Chovnick, 1974). Electrophoretic mobility variants of XDH which map to the rosy locus are readily isolated from laboratory stocks and natural populations of Dro- sophila melanogaster. From these sources, we have established a number of wild-type isoalleles of the rosy locus. These are maintained as stable lines which possess XDH molecules with distinctive electrophoretic mobilities and thermal properties. Moreover, the XDH enzyme activity level associated with each of these wild-type alleles is also a distinc- tive, stable phenotypic character. Table 1 summa- rizes our present array of ry+ isoalleles. The XDH produced by ry+O serves as a mobility standard and is designated XDH1.Oo. Under standard conditions of" @default.
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• W2341596828 date "1977-01-01" @default.
• W2341596828 modified "2023-09-27" @default.
• W2341596828 title "Organization of the Rosy Locus in Drosophila melanogaster Review" @default.
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• W2341596828 hasPublicationYear "1977" @default.
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