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- W2341613737 abstract "SUMMARY Several factors may affect the delivery of a nebulized aerosol to the lung through an endotracheal tube during mechanical ventilation. Tostudy these factors In vitro, a model represent Ing ventilation of an adult patient was constructed by linking a Servo gooe ventilator to a standard humidified circuit and an endotracheal (ET) tube positioned within a pipe representing the trachea. This was connected via a filter to a lung simulator. Nebulizers filled with 1I11mTc human serum albu min were positioned In the circuit, and the delivery of nebulized aerosol through the ET tube Into the filter was measured using a gamma camera. With the use of an Inspiratory phase-activated System 22 Acorn Jet nebulizer, typical adult ventilator settings, and a 3-ml nebulizer solution vol ume, 5.4% of the nebulizer dose reached beyond the end of the ET tube. This was Increased by Increasing the Inspiratory time, reducing the respiratory rate or respiratory minute volume, and by repositioning the nebulizer on the Inspiratory 11mb of the Y-plece and was reduced by slowing the driving gas flow to the nebulizer. Under the same conditions, delivery was 3.1 and 4.4% using the Samsonlc and Flsoneb ultrasonic nebulizers, respectively. Increasing the fill volume and the addi tion of an aerosol storage chamber Increased delivery with all three nebulizers. These experiments suggest some simple ways of Improving aerosol delivery during mechanical ventilation, Including Increasing the volume of nebulizer fill, repositioning the nebulizer In the ventilator circuit, adding an aerosol storage chamber, and adjusting ventilator settings to maximize delivery." @default.
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- W2341613737 date "1992-01-01" @default.
- W2341613737 modified "2023-09-27" @default.
- W2341613737 title "Effect of Ventilator Settings and Nebulizer Type, Position, and Volume of Fi1l 1 - 3" @default.
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