Matches in SemOpenAlex for { <https://semopenalex.org/work/W2341631627> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2341631627 abstract "Background Abatacept is a fusion protein of human CTLA-4 and the Fc portion of human IgG1. It is believed to be effective in the treatment of rheumatoid arthritis by blocking the co-stimulation of T-cells via blocking CD28-B7 interaction as CTLA-4 binds to both B7.1 (CD80) and B7.2 (CD86). However, the interaction of CD28 with B7 is crucial for the activation of naive cells, whereas it is unclear whether the action of already activated CD4+ T-cells, which are readily present in established disease, also depend on this interaction. Objectives The aim of this study was to determine whether the mode of action of Abatacept depends on its ability to halt T-cell activation in established disease. Methods Arthritis was induced in thymectomized male DBA/1 mice by immunisation with bovine collagen type II. The mice were subsequently depleted for CD4+ T-cells. Abatacept or control treatment was started when 80% of the mice showed signs of arthritis. Arthritis severity was monitored by clinical scoring of the paws and anti-collagen antibody levels over time were determined by ELISA. Results Treatment with Abatacept in the absence of CD4+ T-cells resulted in lower disease activity. This was associated with decreasing levels of collagen specific IgG1 and IgG2a antibodies while the antibody levels in control- or CD4+ T-cell-depleted mice increased over time. Conclusions These results show that Abatacept decreased disease activity in the absence of CD4+ T-cells indicating that the mode of action of Abatacept in established arthritis does not entirely depend on its effects on CD4+ T-cell activation. Disclosure of Interest None declared" @default.
- W2341631627 created "2016-06-24" @default.
- W2341631627 creator A5020489800 @default.
- W2341631627 creator A5034377575 @default.
- W2341631627 creator A5044218378 @default.
- W2341631627 creator A5052842332 @default.
- W2341631627 creator A5062465878 @default.
- W2341631627 creator A5063488183 @default.
- W2341631627 creator A5073097950 @default.
- W2341631627 creator A5081942030 @default.
- W2341631627 date "2015-06-01" @default.
- W2341631627 modified "2023-09-29" @default.
- W2341631627 title "THU0046 Abatacept Decreases Disease Activity in the Absence of CD4+ T-Cells in the Collagen Induced Arthritis Model" @default.
- W2341631627 doi "https://doi.org/10.1136/annrheumdis-2015-eular.4012" @default.
- W2341631627 hasPublicationYear "2015" @default.
- W2341631627 type Work @default.
- W2341631627 sameAs 2341631627 @default.
- W2341631627 citedByCount "0" @default.
- W2341631627 crossrefType "journal-article" @default.
- W2341631627 hasAuthorship W2341631627A5020489800 @default.
- W2341631627 hasAuthorship W2341631627A5034377575 @default.
- W2341631627 hasAuthorship W2341631627A5044218378 @default.
- W2341631627 hasAuthorship W2341631627A5052842332 @default.
- W2341631627 hasAuthorship W2341631627A5062465878 @default.
- W2341631627 hasAuthorship W2341631627A5063488183 @default.
- W2341631627 hasAuthorship W2341631627A5073097950 @default.
- W2341631627 hasAuthorship W2341631627A5081942030 @default.
- W2341631627 hasConcept C148125776 @default.
- W2341631627 hasConcept C154317977 @default.
- W2341631627 hasConcept C159654299 @default.
- W2341631627 hasConcept C185592680 @default.
- W2341631627 hasConcept C202751555 @default.
- W2341631627 hasConcept C203014093 @default.
- W2341631627 hasConcept C2776090121 @default.
- W2341631627 hasConcept C2777077863 @default.
- W2341631627 hasConcept C2777575956 @default.
- W2341631627 hasConcept C2778297628 @default.
- W2341631627 hasConcept C2779605438 @default.
- W2341631627 hasConcept C2780653079 @default.
- W2341631627 hasConcept C2781101188 @default.
- W2341631627 hasConcept C39347974 @default.
- W2341631627 hasConcept C55493867 @default.
- W2341631627 hasConcept C71924100 @default.
- W2341631627 hasConcept C8891405 @default.
- W2341631627 hasConceptScore W2341631627C148125776 @default.
- W2341631627 hasConceptScore W2341631627C154317977 @default.
- W2341631627 hasConceptScore W2341631627C159654299 @default.
- W2341631627 hasConceptScore W2341631627C185592680 @default.
- W2341631627 hasConceptScore W2341631627C202751555 @default.
- W2341631627 hasConceptScore W2341631627C203014093 @default.
- W2341631627 hasConceptScore W2341631627C2776090121 @default.
- W2341631627 hasConceptScore W2341631627C2777077863 @default.
- W2341631627 hasConceptScore W2341631627C2777575956 @default.
- W2341631627 hasConceptScore W2341631627C2778297628 @default.
- W2341631627 hasConceptScore W2341631627C2779605438 @default.
- W2341631627 hasConceptScore W2341631627C2780653079 @default.
- W2341631627 hasConceptScore W2341631627C2781101188 @default.
- W2341631627 hasConceptScore W2341631627C39347974 @default.
- W2341631627 hasConceptScore W2341631627C55493867 @default.
- W2341631627 hasConceptScore W2341631627C71924100 @default.
- W2341631627 hasConceptScore W2341631627C8891405 @default.
- W2341631627 hasLocation W23416316271 @default.
- W2341631627 hasOpenAccess W2341631627 @default.
- W2341631627 hasPrimaryLocation W23416316271 @default.
- W2341631627 hasRelatedWork W1481803988 @default.
- W2341631627 hasRelatedWork W1516321396 @default.
- W2341631627 hasRelatedWork W1555634619 @default.
- W2341631627 hasRelatedWork W1588062797 @default.
- W2341631627 hasRelatedWork W1600108156 @default.
- W2341631627 hasRelatedWork W1607912577 @default.
- W2341631627 hasRelatedWork W2008267878 @default.
- W2341631627 hasRelatedWork W2059427290 @default.
- W2341631627 hasRelatedWork W2064529993 @default.
- W2341631627 hasRelatedWork W2091992513 @default.
- W2341631627 hasRelatedWork W2121133002 @default.
- W2341631627 hasRelatedWork W2157731456 @default.
- W2341631627 hasRelatedWork W2603968852 @default.
- W2341631627 hasRelatedWork W2754642665 @default.
- W2341631627 hasRelatedWork W2807402563 @default.
- W2341631627 hasRelatedWork W2901511355 @default.
- W2341631627 hasRelatedWork W2917021924 @default.
- W2341631627 hasRelatedWork W3022920667 @default.
- W2341631627 hasRelatedWork W3091515074 @default.
- W2341631627 hasRelatedWork W3161384404 @default.
- W2341631627 isParatext "false" @default.
- W2341631627 isRetracted "false" @default.
- W2341631627 magId "2341631627" @default.
- W2341631627 workType "article" @default.