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• W2341688897 abstract "Heart failure (HF) is a major health problem whose attributable burden of morbidity and mortality continues to increase as the population ages. 1 The pathogenesis of HF remains incompletely understood. The key pathways implicated include the effect of neurohormonal activation, 2 oxidative stress, 3 and immune activation 4 on myocytes and the interstitium. Several biomarkers have emerged to evaluate the prognosis and progression of HF. Currently, however, no marker is used in the clinical decision making for HF patients. Serum uric acid (SUA) is a byproduct of purine catabolism, the terminal steps of which are catalyzed by xanthine oxidoreductase (XOR). In HF, SUA levels may rise due to increased purine catabolism resulting from tissue hypoxia, apoptosis, and ⁄or enhanced or upregulated XOR activity. 5 Therefore, SUA could be used as a prognostic marker in HF" @default.
• W2341688897 created "2016-06-24" @default.
• W2341688897 creator A5086339268 @default.
• W2341688897 date "2011-01-01" @default.
• W2341688897 modified "2023-09-27" @default.
• W2341688897 title "Uric Acid as a Predictor of All-Cause Mortality in Heart Failure:" @default.
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• W2341688897 hasPublicationYear "2011" @default.
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