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- W2341716903 abstract "Normal hemostaz, uc ana bilefleni olan damar duvar›, trombositler ve plazma proteinlerinin cok s›k› duzenlenmifl koordineli cal›flmas› ile sa¤lan›r. Bu bileflenlerden herhangi birindeki bir bozukluk kanamaya veya tromboza neden olabilir (1, 2). Kan›n ak›flkanl›¤›, reaktanlar›n deriflimini azaltan kan›n kendi ak›m›, koagulasyon faktorlerinin yuzeylere adsorbsiyonu ve plazmadaki bircok inhibitorun varl›¤›yla sa¤lan›r. Antitrombin III (AT), protein C (PC), protein S (PS) ve doku faktoru yola¤› inhibitoru (TFPI) en onemli koagulasyon inhibitorleridir. AT, faktor Girifl ve Amac: Etyolojisinde tromboz olan ve/veya do¤al seyrinde trombotik komplikasyonlarla s›k karfl›lafl›lan gastrointestinal hastal›klarda (portal ven trombozu, Budd-Chiari sendromu, karaci¤er sirozu, inflamatuar barsak hastal›¤› ve gastrointestinal malignite) aktive protein C direnci s›kl›¤› ile protein C, protein S ve antitrombin eksikliklerini araflt›rmak uzere bu prospektif cal›flma planland›. Gerec ve Yontem: Hastalardan fonksiyonel yontemlerle protein C, protein S, antitrombin aktiviteleri ve koagulasyon faktoru V’den yoksun test plazmas› kullan›larak modifiye yontemle aktive protein C direnci araflt›r›ld›. Bulgular: Protein C eksikli¤i siroz, malign ve sekonder portal ven trombozu gruplar›nda di¤er gruplardan daha s›kt› (p<0.05). Primer portal ven trombozu ve Budd-Chiari sendromundaki protein C eksikli¤i ise kontrolden daha fazlayd› (p<0.05). Protein S eksikli¤i Budd-Chiari sendromunda di¤er tum gruplardan istatistiksel onemde fazlayd›. ‹nflamatuar barsak hastal›¤›, malign ve her iki portal ven trombozu grubunda protein S eksikli¤i oran› siroz ve kontrolden yuksekdi (p<0.05). Antitrombin eksikli¤i sirozda di¤er tum gruplardan daha fazlayd›. Aktive protein C direnci varl›¤› oran› tum hasta gruplar›nda kontrolden istatistiksel onemde fazlal›k gosteriyordu (p<0.05). Budd-Chiari sendromunda aktive protein C direnci bulunma oran› ise di¤er tum gruplardan fazlayd› (p<0.05). Ayr›ca sirozlu ve maligniteli hastalarda tromboz varl›¤›yla aktive protein C direnci bulunmas› korelasyon gosteriyordu (p<0.05). Trombofilik faktorlerden iki veya daha fazlas›n›n birarada bulunmas› tromboz riskinde belirgin art›fla neden olmaktayd›. Sonuc: Protein C, protein S ve antitrombin eksikliklerinin ve ozellikle aktive protein C direnci varl›¤›n›n; Budd-Chiari sendromu ve portal ven trombozu etyolojisinde rol oynayabilece¤i, sirozlu, inflamatuar barsak hastal›kl› ve maligniteli hastalarda tromboz geliflme riskini artt›rd›¤› saptand›." @default.
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- W2341716903 date "2010-08-01" @default.
- W2341716903 modified "2023-10-11" @default.
- W2341716903 title "Protein C pathway and antithrombin in thrombosis-related gastrointestinal disorders" @default.
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