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• W2341757872 abstract "AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA389 Acute lymphoblastic leukemia (ALL) is the most frequent malignant disease in childhood. Over 80% of children with this disease can be cured by chemotherapy either alone or in combination with cranial irradiation. Although several non-random recurrent gross genetic aberrations, including chromosomal translocations (e.g., ETV6/RUNX1 , BCR/ABL , MLL/AF4 ) and numerical imbalances (e.g., hyperdiploidy), only a few small systematic genomic characterization approaches have been performed in ALL. Leukemic samples from 399 consecutive pediatric ALL patients were examined by high resolution single-nucleotide polymorphism microarray (SNP-Chip) technique to detect genomic abnormalities. Three common genetic alterations were found: deletion of ETV6 , deletion of P16INK4A and hyperdiploidy. A number of novel recurrent genetic alterations were also detected including deletions at 3p14.2, 3q26.3 and Xp21.2. Uniparental disomy (UPD) was a frequent event in ALL, especially affecting chromosome 9. Children with hyperdiploid ALL without gain of chromosomes 17 and 18 had a poor prognosis. A novel tumor suppressor candidate gene for ALL, SNAP91 on 6q, was frequently inactivated by deletion and/or methylation in ALL. SNP-Chip is a powerful tool to identify small genetic abnormalities which are not detectable by standard techniques, and provides the opportunity for further refining the subclassification and determining the prognosis of childhood ALL." @default.
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• W2341757872 date "2007-05-01" @default.
• W2341757872 modified "2023-09-22" @default.
• W2341757872 title "Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high resolution single nucleotide polymorphism oligonucleotide microarray." @default.
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