FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2341851504> ?p ?o ?g. }

• W2341851504 endingPage "502" @default.
• W2341851504 startingPage "495" @default.
• W2341851504 abstract "Neonatal hyperbilirubinemia is a common clinical condition caused mainly by the increased production and decreased excretion of bilirubin. Current treatment is aimed at reducing the serum levels of bilirubin. Heme oxygenase-1 (HO-1) is a rate-limiting enzyme that generates bilirubin. In this study we intended to suppress HO-1 using the RNA interference technique. Small interfering RNA (siRNA)-A, -B, and -C were designed based on human HO-1 (hHO-1) mRNA sequences. siRNA was transfected into a human hepatic cell line (HL-7702). hHO-1 transcription and protein levels were then determined. In addition, the inhibitory effect of siRNA on hHO-1 was assessed in cells treated with hemin or transfected with an hHO-1 plasmid. siRNA-C showed the most potent suppressive effect on hHO-1. This inhibition is dose and time dependent. Compared with control, both hemin and hHO-1 plasmids up-regulated hHO-1 expression in HL-7702 cells. However, the up-regulation was significantly attenuated by siRNA-C. Furthermore, the decrease in hHO-1 activity was coincident with the suppression of its transcription. Finally, siRNA-C was shown to reduce hHO-1 enzymatic activity and bilirubin levels. Thus, this study provides a novel therapeutic rationale by blocking bilirubin formation via siRNA for preventing and treating neonatal hyperbilirubinemia and bilirubin encephalopathy at an early clinical stage." @default.
• W2341851504 created "2016-06-24" @default.
• W2341851504 creator A5001824731 @default.
• W2341851504 creator A5015668217 @default.
• W2341851504 creator A5015873735 @default.
• W2341851504 creator A5027339124 @default.
• W2341851504 creator A5035934400 @default.
• W2341851504 creator A5056524880 @default.
• W2341851504 creator A5071420879 @default.
• W2341851504 creator A5072699139 @default.
• W2341851504 creator A5073333276 @default.
• W2341851504 date "2007-04-01" @default.
• W2341851504 modified "2023-10-14" @default.
• W2341851504 title "Reduction of bilirubin by targeting human heme oxygenase-1 through siRNA." @default.
• W2341851504 cites W1621595817 @default.
• W2341851504 cites W1887208168 @default.
• W2341851504 cites W1970353140 @default.
• W2341851504 cites W1970544863 @default.
• W2341851504 cites W1976126898 @default.
• W2341851504 cites W1984229257 @default.
• W2341851504 cites W1989327883 @default.
• W2341851504 cites W1996164865 @default.
• W2341851504 cites W2002802490 @default.
• W2341851504 cites W2012188597 @default.
• W2341851504 cites W2021611419 @default.
• W2341851504 cites W2060225756 @default.
• W2341851504 cites W2066079388 @default.
• W2341851504 cites W2073240232 @default.
• W2341851504 cites W2081557156 @default.
• W2341851504 cites W2099244520 @default.
• W2341851504 cites W2126305604 @default.
• W2341851504 cites W2141710909 @default.
• W2341851504 cites W2144005030 @default.
• W2341851504 cites W2144016338 @default.
• W2341851504 cites W2153175562 @default.
• W2341851504 cites W2211965291 @default.
• W2341851504 cites W2367062040 @default.
• W2341851504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17392485" @default.
• W2341851504 hasPublicationYear "2007" @default.
• W2341851504 type Work @default.
• W2341851504 sameAs 2341851504 @default.
• W2341851504 citedByCount "0" @default.
• W2341851504 crossrefType "journal-article" @default.
• W2341851504 hasAuthorship W2341851504A5001824731 @default.
• W2341851504 hasAuthorship W2341851504A5015668217 @default.
• W2341851504 hasAuthorship W2341851504A5015873735 @default.
• W2341851504 hasAuthorship W2341851504A5027339124 @default.
• W2341851504 hasAuthorship W2341851504A5035934400 @default.
• W2341851504 hasAuthorship W2341851504A5056524880 @default.
• W2341851504 hasAuthorship W2341851504A5071420879 @default.
• W2341851504 hasAuthorship W2341851504A5072699139 @default.
• W2341851504 hasAuthorship W2341851504A5073333276 @default.
• W2341851504 hasConcept C104317684 @default.
• W2341851504 hasConcept C105580179 @default.
• W2341851504 hasConcept C126322002 @default.
• W2341851504 hasConcept C153911025 @default.
• W2341851504 hasConcept C166703698 @default.
• W2341851504 hasConcept C181199279 @default.
• W2341851504 hasConcept C185592680 @default.
• W2341851504 hasConcept C22615655 @default.
• W2341851504 hasConcept C2776217839 @default.
• W2341851504 hasConcept C2777513400 @default.
• W2341851504 hasConcept C2777723881 @default.
• W2341851504 hasConcept C2778083895 @default.
• W2341851504 hasConcept C2779219270 @default.
• W2341851504 hasConcept C54009773 @default.
• W2341851504 hasConcept C55493867 @default.
• W2341851504 hasConcept C67705224 @default.
• W2341851504 hasConcept C71924100 @default.
• W2341851504 hasConcept C86803240 @default.
• W2341851504 hasConcept C98274493 @default.
• W2341851504 hasConceptScore W2341851504C104317684 @default.
• W2341851504 hasConceptScore W2341851504C105580179 @default.
• W2341851504 hasConceptScore W2341851504C126322002 @default.
• W2341851504 hasConceptScore W2341851504C153911025 @default.
• W2341851504 hasConceptScore W2341851504C166703698 @default.
• W2341851504 hasConceptScore W2341851504C181199279 @default.
• W2341851504 hasConceptScore W2341851504C185592680 @default.
• W2341851504 hasConceptScore W2341851504C22615655 @default.
• W2341851504 hasConceptScore W2341851504C2776217839 @default.
• W2341851504 hasConceptScore W2341851504C2777513400 @default.
• W2341851504 hasConceptScore W2341851504C2777723881 @default.
• W2341851504 hasConceptScore W2341851504C2778083895 @default.
• W2341851504 hasConceptScore W2341851504C2779219270 @default.
• W2341851504 hasConceptScore W2341851504C54009773 @default.
• W2341851504 hasConceptScore W2341851504C55493867 @default.
• W2341851504 hasConceptScore W2341851504C67705224 @default.
• W2341851504 hasConceptScore W2341851504C71924100 @default.
• W2341851504 hasConceptScore W2341851504C86803240 @default.
• W2341851504 hasConceptScore W2341851504C98274493 @default.
• W2341851504 hasIssue "4" @default.
• W2341851504 hasLocation W23418515041 @default.
• W2341851504 hasOpenAccess W2341851504 @default.
• W2341851504 hasPrimaryLocation W23418515041 @default.
• W2341851504 hasRelatedWork W2021760273 @default.
• W2341851504 hasRelatedWork W2341851504 @default.
• W2341851504 hasRelatedWork W2348666396 @default.
• W2341851504 hasRelatedWork W2352965143 @default.

• next