Matches in SemOpenAlex for { <https://semopenalex.org/work/W2341851664> ?p ?o ?g. }
- W2341851664 endingPage "678" @default.
- W2341851664 startingPage "672" @default.
- W2341851664 abstract "The goal of this study was to investigate whether poly (lactic-co-glycolic) acid (PLGA) nanoparticles could enhance sublingual immunotherapy (SLIT) efficacy. BALB/c mice sensitized to rChe a 3 were treated sublingually either with soluble rChe a 3 (100μg/dose) or PLGA-encapsulated rChe a 3 (5, 25, or 50μg/dose). SLIT with PLGA-encapsulated rChe a 3 (equivalent to 25 and 50μg rChe a 3 per dose) led to significantly increased antigen-specific IgG2a, along with no effect on allergen-specific IgE and IgG1 antibody levels. In addition, interleukin 4 (IL-4) levels in restimulated splenocytes were significantly less, while interferon-γ (IFN-γ), interleukin-10 (IL-10), and transforming growth factor-β (TGF-β) levels, as well as Foxp3 expression, were significantly greater than in the control groups. Our findings suggest that PLGA nanoparticle-based vaccination may help rational development of sublingual immunotherapy through reduction of the needed allergen doses and also significantly enhanced systemic T regulatory (Treg) and T helper 1 (Th1) immune responses." @default.
- W2341851664 created "2016-06-24" @default.
- W2341851664 creator A5002259570 @default.
- W2341851664 creator A5009207901 @default.
- W2341851664 creator A5011939410 @default.
- W2341851664 creator A5055939527 @default.
- W2341851664 creator A5065942417 @default.
- W2341851664 date "2015-12-01" @default.
- W2341851664 modified "2023-09-29" @default.
- W2341851664 title "Down-regulation of Th2 immune responses by sublingual administration of poly (lactic-co-glycolic) acid (PLGA)-encapsulated allergen in BALB/c mice" @default.
- W2341851664 cites W1576438536 @default.
- W2341851664 cites W1965359442 @default.
- W2341851664 cites W1968428761 @default.
- W2341851664 cites W1969772900 @default.
- W2341851664 cites W1970166280 @default.
- W2341851664 cites W1974629753 @default.
- W2341851664 cites W1977784751 @default.
- W2341851664 cites W1978132780 @default.
- W2341851664 cites W1990734052 @default.
- W2341851664 cites W1993797541 @default.
- W2341851664 cites W2003110090 @default.
- W2341851664 cites W2004554125 @default.
- W2341851664 cites W2006560691 @default.
- W2341851664 cites W2006777849 @default.
- W2341851664 cites W2007909136 @default.
- W2341851664 cites W2009482020 @default.
- W2341851664 cites W2012260545 @default.
- W2341851664 cites W2020912475 @default.
- W2341851664 cites W2022278076 @default.
- W2341851664 cites W2031837233 @default.
- W2341851664 cites W2033852067 @default.
- W2341851664 cites W2034257631 @default.
- W2341851664 cites W2050131389 @default.
- W2341851664 cites W2052063445 @default.
- W2341851664 cites W2057572412 @default.
- W2341851664 cites W2060632937 @default.
- W2341851664 cites W2064805188 @default.
- W2341851664 cites W2068471769 @default.
- W2341851664 cites W2068736091 @default.
- W2341851664 cites W2077121225 @default.
- W2341851664 cites W2080652842 @default.
- W2341851664 cites W2085255220 @default.
- W2341851664 cites W2087253732 @default.
- W2341851664 cites W2092967539 @default.
- W2341851664 cites W2096210343 @default.
- W2341851664 cites W2097731012 @default.
- W2341851664 cites W2114556585 @default.
- W2341851664 cites W2125222146 @default.
- W2341851664 cites W2126816655 @default.
- W2341851664 cites W2132441138 @default.
- W2341851664 cites W2136712715 @default.
- W2341851664 cites W2143789950 @default.
- W2341851664 cites W2155645788 @default.
- W2341851664 cites W2155800341 @default.
- W2341851664 cites W2161040169 @default.
- W2341851664 cites W2165648644 @default.
- W2341851664 cites W2168079344 @default.
- W2341851664 cites W4238726741 @default.
- W2341851664 cites W4239393922 @default.
- W2341851664 doi "https://doi.org/10.1016/j.intimp.2015.09.011" @default.
- W2341851664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26404189" @default.
- W2341851664 hasPublicationYear "2015" @default.
- W2341851664 type Work @default.
- W2341851664 sameAs 2341851664 @default.
- W2341851664 citedByCount "31" @default.
- W2341851664 countsByYear W23418516642017 @default.
- W2341851664 countsByYear W23418516642018 @default.
- W2341851664 countsByYear W23418516642019 @default.
- W2341851664 countsByYear W23418516642020 @default.
- W2341851664 countsByYear W23418516642021 @default.
- W2341851664 countsByYear W23418516642022 @default.
- W2341851664 countsByYear W23418516642023 @default.
- W2341851664 crossrefType "journal-article" @default.
- W2341851664 hasAuthorship W2341851664A5002259570 @default.
- W2341851664 hasAuthorship W2341851664A5009207901 @default.
- W2341851664 hasAuthorship W2341851664A5011939410 @default.
- W2341851664 hasAuthorship W2341851664A5055939527 @default.
- W2341851664 hasAuthorship W2341851664A5065942417 @default.
- W2341851664 hasConcept C141105273 @default.
- W2341851664 hasConcept C147483822 @default.
- W2341851664 hasConcept C159654299 @default.
- W2341851664 hasConcept C185592680 @default.
- W2341851664 hasConcept C189976730 @default.
- W2341851664 hasConcept C202751555 @default.
- W2341851664 hasConcept C203014093 @default.
- W2341851664 hasConcept C2775920511 @default.
- W2341851664 hasConcept C2777701055 @default.
- W2341851664 hasConcept C2777863537 @default.
- W2341851664 hasConcept C2779727006 @default.
- W2341851664 hasConcept C2780165375 @default.
- W2341851664 hasConcept C2780472526 @default.
- W2341851664 hasConcept C2911179620 @default.
- W2341851664 hasConcept C523546767 @default.
- W2341851664 hasConcept C54355233 @default.
- W2341851664 hasConcept C55493867 @default.
- W2341851664 hasConcept C71924100 @default.
- W2341851664 hasConcept C86803240 @default.
- W2341851664 hasConcept C8891405 @default.