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- W2341904425 endingPage "407" @default.
- W2341904425 startingPage "407" @default.
- W2341904425 abstract "The natural history of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT) is dismal (approximately 2-4 mo), and PVTT is reportedly found in 10%-40% of HCC patients at diagnosis. According to the Barcelona Clinic Liver Cancer (BCLC) Staging System (which is the most widely adopted HCC management guideline), sorafenib is the standard of care for advanced HCC (i.e., BCLC stage C) and the presence of PVTT is included in this category. However, sorafenib treatment only marginally prolongs patient survival and, notably, its therapeutic efficacy is reduced in patients with PVTT. In this context, there have been diverse efforts to develop alternatives to current standard systemic chemotherapies or combination treatment options. To date, many studies on transarterial chemoembolization, 3-dimensional conformal radiotherapy, hepatic arterial chemotherapy, and transarterial radioembolization report better overall survival than sorafenib therapy alone, but their outcomes need to be verified in future prospective, randomized controlled studies in order to be incorporated into current treatment guidelines. Additionally, combination strategies have been applied to treat HCC patients with PVTT, with the hope that the possible synergistic actions among different treatment modalities would provide promising results. This narrative review describes the current status of the management options for HCC with PVTT, with a focus on overall survival." @default.
- W2341904425 created "2016-06-24" @default.
- W2341904425 creator A5039487186 @default.
- W2341904425 date "2016-01-01" @default.
- W2341904425 modified "2023-10-05" @default.
- W2341904425 title "Treatment of hepatocellular carcinoma with portal venous tumor thrombosis: A comprehensive review" @default.
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- W2341904425 doi "https://doi.org/10.3748/wjg.v22.i1.407" @default.
- W2341904425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4698503" @default.
- W2341904425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26755886" @default.
- W2341904425 hasPublicationYear "2016" @default.
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