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• W2341923639 abstract "Under covariate adaptive randomization, the covariate is tied to both randomization and analysis. Misclassification of such covariate will impact the intended treatment assignment; further, it is unclear what the appropriate analysis strategy should be. We explore the impact of such misclassification on the trial’s statistical operating characteristics. Simulation scenarios were created based on the misclassification rate and the covariate effect on the outcome. Models including unadjusted, adjusted for the misclassified, or adjusted for the corrected covariate were compared using logistic regression for a binary outcome and Poisson regression for a count outcome. For the binary outcome using logistic regression, type I error can be maintained in the adjusted model, but the test is conservative using an unadjusted model. Power decreased with both increasing covariate effect on the outcome as well as the misclassification rate. Treatment effect estimates were biased towards the null for both the misclassified and unadjusted models. For the count outcome using a Poisson model, covariate misclassification led to inflated type I error probabilities and reduced power in the misclassified and the unadjusted model. The impact of covariate misclassification under covariate–adaptive randomization differs depending on the underlying distribution of the outcome." @default.
• W2341923639 created "2016-06-24" @default.
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• W2341923639 date "2015-11-23" @default.
• W2341923639 modified "2023-09-30" @default.
• W2341923639 title "The impact of covariate misclassification using generalized linear regression under covariate–adaptive randomization" @default.
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• W2341923639 doi "https://doi.org/10.1177/0962280215616405" @default.
• W2341923639 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5476516" @default.
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