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• W2341936878 abstract "Sinomenine, a pure alkaloid extract from Sinomenium acutum, has anti-inflammatory and immuno- regulatory functions. This study investigated the efficiency and the signalling pathways involved in the effect of sin- omenine on vascular smooth muscle cell (VSMC) dedif- ferentiation in response to platelet-derived growth factor (PDGF)-BB stimulation and vascular injury. VSMCs were isolated from rat aorta and preincubated with sinomenine before being stimulated with PDGF-BB. WST and BrdU incorporation assays were used to evaluate VSMC prolif- eration. Flow cytometric analysis was performed for testing the cell cycle progression. The cell migration of VSMCs were analysed using a Transwell system. The expression of VSMC specific genes and signalling proteins were tested by Western blot. For the animal study, C57/BL6 mice were fed either normal rodent chow diets or sinomenine chow diets that supplemented with 0.09 % sinomenine (w/w) in the normal chows for 14 days before carotid artery wire injury. PDGF-BB activated the dedifferentiation of VSMCs characterised by decreased expression of SMA, Smoothelin and SM22a. However, sinomenine treatment preserved the dedifferentiation in response to PDGF-BB. The activations of mitogen-activated protein kinase extra- cellular signal-regulated kinases, Akt, GSK3b and STAT3 induced by PDGF-BB were also inhibited in sinomenine- treated VSMCs. In vivo evidence with wire-injured mice exhibited a reduction in neointimal area and an increase in smooth muscle-specific gene expression in the sinomenine- treated group. In this study, we found that sinomenine- suppressed VSMC phenotype switching induced by PDGF-BB in vitro and neointimal formation in vivo. Therefore, sinomenine is a potential candidate to be used in the treatment of vascular proliferative disease." @default.
• W2341936878 created "2016-06-24" @default.
• W2341936878 creator A5037720655 @default.
• W2341936878 date "2013-01-01" @default.
• W2341936878 modified "2023-09-27" @default.
• W2341936878 title "Effect of sinomenine on vascular smooth muscle cell dedifferentiation and neointima formation after vascular injury in mice Lihua ZhuYarong HaoHongjing GuanChangping Cui • Song TianDa YangXinan WangShuming Zhang •" @default.
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• W2341936878 hasPublicationYear "2013" @default.
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